Alzheimers Therapeutics Market (By Product: Cholinesterase Inhibitors, Pipeline Drugs; By End Use) - Global Industry Analysis, Size, Share, Growth, Trends, Revenue, Regional Outlook and Forecast 2022-2030

Published Date : Aug 2022 | No. of Pages : 150+ Pages | Category : Healthcare

The global Alzheimer's therapeutics market size was estimated at around USD 4.11 billion in 2021 and it is projected to hit around USD 15.8 billion by 2030, growing at a CAGR of 16.14% from 2022 to 2030

Alzheimer's Therapeutics Market Size 2021 to 2030

Report Highlights

  • The cholinesterase inhibitors segment held the largest revenue share of over 50.2% in 2021.
  • The pipeline drugs segment is expected to witness the fastest growth over the forecast period.
  • The hospital pharmacy segment dominated the market in 2021 with a revenue share of over 55.04%.
  • North America dominated the market with a share of over 40.23% in 2021 and is anticipated to grow at a significant rate over the forecast period. 
  • The Asia Pacific region is expected to emerge as the fastest-growing region over the forecast period.

Government organizations are engaged in providing funds for Alzheimer's support, care, and research activities, which is projected to fuel the market growth. For instance, in March 2022, the Alzheimer's Society announced to spend around USD 3.5 billion in the coming years on dementia research to improve the care of patients.

Additionally, the Alzheimer's Association with the Alzheimer's Impact Movement (AIM) announced to utilize USD 25 million to implement the BOLD Infrastructure for Alzheimer's Act to create an effective public health substructure for patients. In addition, in September 2021, the South Texas Alzheimer's Disease Center and the Duke/University of North Carolina Alzheimer's Disease Research Center were granted USD 14.8 million over five years by the National Institute of Aging to encourage research on risk factors related to AD. 

Furthermore, an increase in the incidence and cost burden of dementia associated with AD is expected to boost the market growth. According to the Alzheimer's Society, around 900,000 people are living with dementia in the United Kingdom, and it is projected to rise to 1.6 million by 2040 and the incidence of dementia will be 209,600 in the same year. 

The current standard of care is limited to symptom-relieving drugs. Therefore, the approval of disease-modifying anti-amyloid therapeutics is expected to change the treatment landscape. For instance, in June 2021, the U.S. FDA granted accelerated approval to Aduhelm (aducanumab) for the treatment of patients with Alzheimer’s disease. It is a monoclonal antibody that targets cluster forms of amyloid beta present in the brains of patients and stops its formation. Other key anti-amyloid monoclonal antibodies in late-stage clinical trials include Gantenerumab (F. Hoffmann-La Roche Ltd.), Solanezumab (Eli Lilly and Company), and Lecanemab (Eisai Inc./Biogen), among others. 

Scope of The Report

Report Coverage Details
Market Size in 2021 USD 4.11 billion
Revenue Forecast by 2030 USD 15.8 billion
Growth rate from 2022 to 2030 CAGR of 16.14%
Base Year 2021
Forecast Period 2022 to 2030
Segmentation Product, end-user, region
Companies Covered Eisai Co., Ltd.; Novartis AG; AbbVie Inc. (Allergan Plc.); Adamas Pharmaceuticals, Inc.; H. Lundbeck A/S; Biogen; AC Immune; F. Hoffmann La Roche Ltd.; Daiichi Sankyo Company, Limited; Johnson & Johnson Services, Inc.; TauRx Pharmaceuticals Ltd.

 

Product Insights

The cholinesterase inhibitors segment held the largest revenue share of over 50.2% in 2021 as it is the standard of care for Alzheimer’s treatment. In March 2022, the U.S. FDA approved the cholinesterase inhibitor Adlarity (donepezil hydrochloride) developed by Corium Inc., for the treatment of patients with severe dementia of Alzheimer’s disease (AD). It is a transdermal patch administered once a week and delivers a stable dose of donepezil and was the fourth cholinesterase drug approved and launched in the U.S. Based on product, the market is divided into cholinesterase inhibitors, NMDA receptor antagonists, combination drugs, and pipeline drugs. 

The pipeline drugs segment is expected to witness the fastest growth over the forecast period owing to the impending launch of multiple disease-modifying therapies. Companies such as F. Hoffmann La Roche Ltd.; Biogen/Eisai Inc.; and Eli Lilly and Company have drug candidates under development that will modify the treatment landscape of AD. According to Alzheimer’s Association, there were 143 drug candidates in 172 clinical trials for AD. Of these, 31 drug candidates in phase 3 clinical trial, 82 drug candidates in phase 2, and 30 drug candidates in phase 1. Successful completion of trials and subsequent approval of these products are anticipated to boost the market growth. 

End-user Insights

The hospital pharmacy segment dominated the market in 2021 with a revenue share of over 55.04% owing to the increasing hospitalization due to a rise in the geriatric population and Alzheimer’s patients. According to Alzheimer’s Association report 2022, there are 518 hospitalizations per 1,000 Medicare beneficiaries in the geriatric population having Alzheimer’s or other dementias as compared to only 234 hospitalizations per 1,000 Medicare beneficiaries without these conditions. However, the total number of hospitalizations of AD patients is expected to remain low compared to the prevalence of Alzheimer’s disease.

The e-commerce segment is expected to expand at a CAGR of 15.33% over the forecast period. An increase in the usage of the internet and smartphone, ease of ordering medications through an e-commerce platform, and increasing e-commerce services globally are expected to fuel the segment growth in the coming years. 

Regional Insights

North America dominated the market with a share of over 40.23% in 2021 and is anticipated to grow at a significant rate over the forecast period. The growing research for the treatment of Alzheimer’s is propelling the market growth. In June 2021, Eisai Co., Ltd. and Biogen's product lecanemab (BAN2401), an anti-amyloid beta protofibril antibody for treating Alzheimer's disease, was granted the Breakthrough Therapy designation by the U.S. FDA. Moreover, the increasing government initiatives and funding are expected to boost the growth of the market. 

The Asia Pacific region is expected to emerge as the fastest-growing region over the forecast period owing to increasing awareness among people and the increasing research activities to develop novel drugs to treat AD. In 2022, there are around 487,500 Australians living with dementia and this number is expected to increase to 1.1 million by 2058. Dementia is the second leading cause of death in Australia. 

Key Players

  • Eisai Co., Ltd.
  • Novartis AG
  • AbbVie Inc. (Allergan Plc.)
  • Adamas Pharmaceuticals, Inc.
  • H. Lundbeck A/S
  • Biogen
  • AC Immune
  • F. Hoffmann La Roche Ltd.
  • Daiichi Sankyo Company, Limited
  • Johnson & Johnson Services, Inc.
  • TauRx Pharmaceuticals Ltd. 

Market Segmentation

  • By Product Outlook
    • Cholinesterase Inhibitors
    • NMDA Receptor Antagonist
    • Combination Drug
    • Pipeline Drugs
  • By End-user Outlook
    • Hospital Pharmacy
    • Retail Pharmacy
    • E-commerce
  • By Regional Outlook
    • North America
      • U.S.
      • Canada
    • Europe
      • Germany
      • U.K.
      • France
      • Italy
      • Spain
    • Asia Pacific
      • Japan
      • China
      • India
      • Australia
      • South Korea
    • Latin America
      • Brazil
      • Mexico
      • Argentina
    • Middle East and Africa (MEA)
      • South Africa
      • Saudi Arabia
      • UAE

 


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