Over the past 30 years, bioadhesives have changed surgery with increasing significance and rapid progress. Bioadhesives have less possibility to harm tissues than conventional invasive wound closure techniques like sutures, wires, and staples, and they can hasten wound healing in a variety of ways. The bioadhesives, for instance, have antioxidant, anti-inflammatory, and antibacterial effects. The simple use of bioadhesives is considerably increased by additional characteristics like self-healing and injectability.
A vital function of bioadhesives is to stop leaks. After surgery, wound leakage is a common occurrence and can pose serious infections in difficult circumstances. Infections, inflammation, pain, and a high death rate are all likely outcomes of the wound leak. With an effort to prevent post-operative leakages, companies have been developing bioadhesives accordingly. For instance, Integra LifeSciences have developed DuraSeal, a spine sealant system. Similarly, Baxter International has been manufacturing COSEAL, a surgical sealant which is commonly used to prevent postoperative bleeding.
Since, bioadhesives are used in all fields, the application segment has been trifurcated as:
One of the most often uses for bioadhesives is wound closure. For many years, wound closure was performed using sutures, wires, and staples. However, questions like the complex postoperative care, scar tissues, secondary damage, wicking-induced infection, foreign body reaction, and hindered wound healing process still need to be addressed. Bioadhesives are expected to be a good substitute as they may bind two wounds together without causing any harm.
However, firm adhesion is required to bring two injury sides together to completely seal the wound. Moreover, the applied bioadhesives should be biocompatible & should not hinder the wound healing process. Along with strong adhesion, the bioadhesives should also have a better cohesion strength.
The most popular tissue adhesives for wound closure are those based on cyanoacrylate. However, due to their water-initiated cure, their applications on moist tissues are constrained. Additionally, they raise safety issues with regard to exothermic polymerization, cytotoxic breakdown products, and prolonged degradation. Thus, there’s an opportunity to produce biocompatible bioadhesives that can be used in wet conditions as well.