Bone Grafts and Substitutes Market (By Material Type: Allograft, Synthetic, Composites, Polymers, Bone Morphogenic Proteins (BMP); By Application: Craniomaxillofacial, Dental, Foot & Ankle, Joint Reconstruction, Long Bone, Spinal Fusion) - Global Industry Analysis, Size, Share, Growth, Trends, Revenue, Regional Outlook 2022 – 2030

Published Date : Jan 2022 | No. of Pages : 150+ Pages | Category : Healthcare

The global bone grafts and substitutes market size was valued at USD 2.80 billion in 2020, and is predicted to be worth around USD 3.96 billion by 2030, registering a CAGR of 6.1% during the forecast period 2022 to 2030.

Bone Grafts and Substitutes Market Size 2022 to 2030

Growth Factors

The rising incidence of bone and joint disorders, increasing demand for dental bone grafts, growing requirement for dental bone grafts, and technological advancements are some key factors driving the market. The synthetic material type segment is anticipated to witness significant growth over the forecast period. This growth is due to the lesser risk of disease transmission, better acceptance among patients as compared to allografts, and products’ better biocompatibility.

One of the key factors fueling the growth of the market is the rising incidence of bone and joint disorders. According to the CDC report, the global incidence rate of hip fracture is expected to rise by 240% in women and 310% in men. Osteoporosis is estimated to affect around 200 million women worldwide. Moreover, the rising demand for dental bone grafts is expected to drive the market for bone grafts and substitutes over the forecast period.

The demand for orthopedic devices, which include bone grafts and substitutes, observed a radical decrease because of the rescheduling of elective surgeries during COVID-19. During the pandemic, various players in the market were negatively impacted and hence they adopted various strategies to deal with the pandemic. 

Growing cases of spinal deformities are driving this market. According to a CDC report, approximately 60% of the aged population and 32% of the adult population are suffering from spinal deformities, in the U.S., as of 2017. Around 488,000 spinal procedures were performed in the U.S. Moreover, the introduction of biocompatible synthetic grafts is expected to fuel market growth. 

Report Coverage

Report Scope Details
Market Size US$ 3.96 billion by 2030
Growth Rate CAGR of 6.1% From 2022 to 2030
Largest Market North America
Base Year 2021
Forecast Period 2022 to 2030
Segments Covered Material type, Application
Regional Scope North America, Europe, Asia Pacific, Latin America, Middle East & Africa
Companies Mentioned Allo Source; Baxter; DePuy Synthes, Inc.; Medtronic; Nuvasive, Inc.; Orthofix Holdings, Inc.; Smith & Nephew, Inc.; Stryker Corporation; Wright Medical Group N.V.; OST Devloppement; Zimmer Biomet; GeistlichPharma AG; TBF Tissue Engineering; Biobank

By Application Analysis

The spinal fusion segment held the largest revenue share of over 60.0% in 2021. Based on application, the market is classified into long bone, spinal fusion, foot and ankle, joint reconstruction, craniomaxillofacial, and dental.

The growth can be attributed to the rising adoption of bone graft materials for spondylosyndesis. Moreover, the rising geriatric population prone to orthopedic ailments is pushing the need for corrective surgical treatment, thereby anticipated to boost the market growth in the near future.

Increasing usage of grafts for dental procedures is estimated to provide lucrative opportunities for the segment to grow through the forecast period. The grafts are usually used as a scaffold and filler in order to facilitate bone formation and promote healing. 

The joint reconstruction segment is expected to witness steady growth over the forecast period owing to the increasing number of knee replacement and hip replacement procedures. According to the center for orthopedic and neurological care and research, the number of total knee replacement surgeries is estimated to increase by 673% to 3.5 million procedures annually, by 2030. 

By Material Type Analysis

The allograft segment led the market and accounted for over 55.0% share of the global revenue in 2021. The allograft segment is further divided into the demineralized bone matrix and others

The adoption of allografts is increasing due to their properties, such as immediate structural support and osteoconductivity. Additionally, they do not require another surgery bone, which triggers fast wound healing and decreases the surgery time.

The synthetic segment is anticipated to witness significant growth over the forecast period. This growth is due to the products’ better biocompatibility, lesser risk of disease transmission, and better acceptance among patients as compared to allografts. 

The synthetic segment is further classified into composites, ceramics, polymers, and BMP. The ceramics segment dominated the market in 2021 and is further sectioned into HAP, ß-TCP, α-TCP, bi-phasic calcium phosphates (BCP), and others. Ceramic material gets easily reabsorbed in a patient’s body, which maintains the position of their bone and has a reduced risk of infection or disease transmission.

By Regional Analysis

North America dominated the market with over 40.0% share of the global revenue in 2021. Growing awareness related to the commercially accessible innovative products, accessibility of a well-developed healthcare structure, and higher healthcare expenditure of 16.9% in 2018 is the major aspects contributing to the regional market growth.

Asia Pacific is estimated to witness lucrative growth during the forecast period. This growth can be attributed to rising medical tourism and favorable government initiatives. On the other hand, stringent regulatory guidelines restrict the adoption in a few nations.

Key Players

  • AlloSource

  • DePuySynthes, Inc.

  • Baxter

  • Nuvasive, Inc.

  • Smith & Nephew

  • Medtronic

  • Orthofix Holdings, Inc.

  • TBF Tissue Engineering

  • OST Devloppement

  • Zimmer Biomet

  • Wright Medical Group N.V.

  • GeistlichPharma AG

  • Stryker Corporation

  • Biobank

Market Segmentation

  • By Material Type 

    • Allograft

      • Demineralized Bone Matrix

      • Others

    • Synthetic

      • Ceramics

        • HAP

        • β-TCP

        • α-TCP

        • Bi-phasic Calcium Phosphates (BCP)

        • Others

      • Composites

      • Polymers

      • Bone Morphogenic Proteins (BMP)

  • By Application 

    • Craniomaxillofacial

    • Dental

    • Foot & Ankle

    • Joint Reconstruction

    • Long Bone

    • Spinal Fusion

  • Regional

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

      • France

      • Italy

      • Spain

    • Asia Pacific

      • China

      • India

      • Japan

      • South Korea

    • Latin America

      • Brazil

      • Mexico

    • MEA

      • South Africa

The bone grafts and substitutes market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of bone grafts and substitutes market for the base year 2021 and the forecast between 2022 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global bone grafts and substitutes market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the bone grafts and substitutes market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted bone grafts and substitutes market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the bone grafts and substitutes capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of bone grafts and substitutes by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global bone grafts and substitutes market. These figures have been provided in terms of both revenue and volume for the period 2019 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major bone grafts and substitutes market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of bone grafts and substitutes market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the bone grafts and substitutes industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

bone grafts and substitutes market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to bone grafts and substitutes market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of bone grafts and substitutes market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new bone grafts and substitutes market. These factors have benefited the growth of the global market for bone grafts and substitutes. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for bone grafts and substitutes. The global market is segmented on the basis of region, application, end-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of bone grafts and substitutes are as follows:

  • History Year: 2019-2020
  • Base Year: 2021
  • Forecast Year 2022  to 2030

Reasons to Purchase this Report:


- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2019-2021) and forecast (2022-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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