Cell Line Development Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2030

Published Date : Apr 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global Cell Line Development market size is expected to be worth around US$ 16.24 billion by 2030, according to a new report by Vision Research Reports.

The global Cell Line Development market size was valued at US$ 12.67 billion in 2020 and is anticipated to grow at a CAGR of 22.9% during forecast period 2021 to 2030.

Growth Factors

The Increasing demand for monoclonal antibodies and patent expiration of blockbuster biologics are expected to drive the cell line development industry over the forecast period.

Increasing prevalence of autoimmune diseases and cancer is likely to increase the demand for accurate and cost-effective treatment options which is expected to render a positive impact on market growth. In addition, improving healthcare infrastructure, economic development and favorable government initiatives promoting the growth of the biotechnology industry are factors contributing towards the growth of the cell line development market.

Ongoing R&D for stable & authentic cell lines and the introduction of technologically advanced processes such as single-use bioreactor and microbioreactor for large scale bioproduction are further expected to provide this market with lucrative future growth opportunities.

Report Highlights

Reagents and media accounted for the largest revenue share as of 2014 due to increasing bio-production that requires these products from incubation to preservation. These products are cost-intensive nature and have repetitive use in the production of biologics hence accounted for the largest revenue share.

Reagents used are attachments and matrix factors, antibiotics, biological buffers, cell freezing, separation and dissociation reagents, and other miscellaneous reagents. Media and salt are essential in bio-production as they provide nutrients to cells and fuel the growth. Some of the most commonly used products are Hans F-10 media, RPMI media, medium 199, MEM media, and DMEM media.

Equipment used are incubators, bioreactors, storage equipment, centrifuge, and microscopes. Bioreactors held the dominant share as of 2014 in the equipment segment due to its usage in large-scale manufacturing of biologics. The introduction of single-use bioreactors is a major driver contributing to the growth of the bioreactor segment over the forecast period. Single-use bioreactors are accompanied by advantages such as cost-effectiveness, time management, and protection against cross-contamination.

On the other hand, the accessories and consumables segment is anticipated to show lucrative growth due to the rising adoption of disposables in these procedures. Increasing laboratory setups for biologics production and R&D activities is attributing to this.

Cell lines development is initiated via organs or tissues collected from mammalians or non-mammalian sources. The source selection is a prerequisite for the development of stable cell lines for commercial purposes. Rising adoption of a mammalian source for the monoclonal antibodies production and the need for expressing complex proteins similar to human beings are expected to boost the adoption of this segment in the coming years.

In addition, enhanced cell engineering and expression systems for this source development are expected to propel the demand.  There are over 4,000 mammalian cell lines available for the use in biologics production and research is going on for the introduction of a few more. This is expected to serve the mammalian source segment with lucrative opportunities.

In general, this technology is based on Glutamine Synthetase (GS) system or methotrexate (MTX) amplification technology. However, the clones produced by these technologies are heterogeneous in nature and hence need to be screened for the selection of stable high productive cell clones and require six to twelve months.

Advancements in clone screening and protein expression in the mammalian source to improve efficiency and speed of producing highly productive cell lines on large-scale production of therapeutic proteins are the factors responsible for segment spearheading.

Type Insights

The recombinant segment accounted for the largest revenue share as of 2014 due to its wide applications in protein interactions, gene activation, and biologics production methods. Furthermore, rising demand for toxicity testing and drug screening are anticipated to fuel the demand in the coming years.

Increase in demand for biologic therapeutics to treat autoimmune disorders, and cancer is the key contributing factor for the high adoption of recombinant proteins during the forecast period. These products are enzymes, blood factors, monoclonal antibodies, hormones, and antibody-related molecules. There are around 650 protein therapeutics approved globally, out of which more than 400 products are recombinant.

Cell line development is an important step in recombinant protein production. The lucrative growth of these proteins due to advancements in expression vector design, clone screening, and cell engineering technologies. Increasing focus on the development of monoclonal cell lines that are stable & consistently expressing the protein with high quality is also expected to fuel the segment growth in the coming years.

Primary cell culture is the fastest-growing segment due to its wide application in genetics, cell morphology, cell metabolism, and physiology. Cell culture is initiated from embryonic, normal, and malignant tissues. From single blood cells, a variety of cells are produced, hence, primary cell cultures are often mixed and grow in in-vitro conditions. The increasing demand for in vitro production of biologics is expected to fuel the demand for this segment during the forecast period.

Cell line development found the largest significance and application in the bio-production of biosimilars, biologics, vaccines, a therapeutic protein, and Mabs. Increasing prevalence of chronic diseases such as cancer and autoimmune diseases is pushing demand for faster and effective therapeutics.

The bioproduction segment accounted for the largest revenue share in 2014 owing to increasing antibiotic and vaccine production. Production of biologics based therapeutic drugs including vaccines, therapeutic proteins, cell therapies, and gene therapies together constitutes the bioproduction application segment. Antibiotics and vaccine production are the most prominent applications of bioproduction and the demand is expected to grow exponentially in the future due to the rise of pandemic and communicable diseases especially in the developing economies.

Currently available vaccines produced by this technology are polio vaccines produced by monkey kidney and neoplastic cell lines. Therapeutic protein is one of the rapidly growing industries due to molecular engineered proteins with optimal target recognition, bio-distribution, pharmacokinetics, and therapeutic functioning.

The bioproduction segment is driven by factors such as increasing in-vitro research activities, safety and efficacy concerns about the product, introduction of biosimilars, and high demand for cellular medicines. Commonly used cell lines for the production of biologics are CHO, GS-knockout CHO-K1, CHO-K1, 293T, HEK293, 293EC18/CRE-Luc, 1321N1, 293EC18, U-2OS, and RH7777 

North America regional market is accounted for the largest revenue share as of 2014 due to the presence of constant technological developments followed by new discoveries triggering the adoption of novel procedures for bioproduction. The presence of rigorous initiatives conducted by research organizations functioning in this region such as Thermo Fisher Scientific Inc., American Type Culture Collection (ATCC), and Sigma-Aldrich Corporation which provide high-quality biologics services is attributing toward the growth.

In addition, supportive government initiatives and growing awareness pertaining to monoclonal antibodies application in cancer treatment are some of the factors expected to drive the regional industry growth.

Asia Pacific regional market is anticipated to witness lucrative growth owing to increasing expenditure on healthcare by government and private sector companies. The biotechnology industry in developing economies is expected to show significant growth during the forecast period. In the developing economies, government initiatives such as public healthcare programs and improved healthcare infrastructure are contributing to the growth of the biotechnology sector.

For instance, in India, organizations such as the Department of Science and Technology (DST), Department of Scientific & Industrial Research (DSIR) and Department of Biotechnology (DBT) are regulating the production and guidelines for biotechnology products. These organizations provide guidelines related to manufacture or transfer technology, raising funds, and generating manpower for production.  Initiatives like these are expected to fuel the growth over the forecast period.

Key Players

GE Healthcare, Lonza Group AG, Sartorious AG, WuXi AppTec Inc., Sigma-Aldrich Corporation, Selexis SA, Thermo Fisher Scientific Inc., and Corning Inc.

Market Segmentation

  • Product Outlook 

    • Reagents and media

    • Equipment

      • Incubators

      • Centrifuges

      • Bioreactors

      • Storage equipment

      • Microscopes

    • Accessories and consumables

  • Source Outlook

    • Mammalian cell line

    • Non-mammalian cell line

      • Insects

      • Amphibians

  • Type of Cell Line Outlook 

    • Recombinant cell lines

    • Hybridomas

    • Continuous cell lines

    • Primary cell lines

  • Application Outlook

    • Bioproduction

    • Drug discovery

    • Toxicity testing

    • Tissue engineering

    • Research

  • Regional Outlook 

    • North America

      • The U.S.

      • Canada

    • Europe

      • The U.K.

      • Germany

    • Asia Pacific

      • Japan

      • China

      • India

    • Latin America

      • Brazil

      • Mexico

    • The Middle East & Africa

      • South Africa

The Cell Line Development market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Cell Line Development market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Cell Line Development market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Cell Line Development market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Cell Line Development market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Cell Line Development capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Cell Line Development by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Cell Line Development market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Cell Line Development market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Cell Line Development market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Cell Line Development industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The Cell Line Development market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Cell Line Development market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Cell Line Development market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Cell Line Development market. These factors have benefited the growth of the global market for Cell Line Development. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Cell Line Development. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Cell Line Development are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market

To strategically profile the key players and comprehensively analyze their growth strategies.

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