The global Downstream Processing market size is expected to be worth around US$ 79.6 billion by 2030, according to a new report by Vision Research Reports.
The global Downstream Processing market size was valued at US$ 21.4 billion in 2020 and is anticipated to grow at a CAGR of 15.9% during forecast period 2021 to 2030.
The capacity requirements during the development of biologic drugs have changed over the past few years, wherein the demand for manufacturing high-volume products has shifted to developing small-volume, high potency products. This creates new avenues for single-use technologies.
As adoption of small-scale, single-use systems for process development and downstream processing is already high, evolutionary changes are expected in the area of single-use technologies for manufacturing small-volume, highly potent drugs. The development of novel film chemistries, closed systems, automation in clinical-scale single-use systems, and smart sensors are some noteworthy advancements in the field.
A rise in applications of downstream processing for the manufacture of biopharmaceuticals is expected to bring growth opportunities to the market. This has also led to an increase in strategic deals and development in the market. For instance, in February 2021, Evozyne, LLC collaborated with a leading rare disorders drug manufacturer for the manufacture and marketing of novel biopharmaceuticals for immune modulation.
The chromatography systems segment dominated the market for downstream processing and accounted for the largest revenue share of 40.6% in 2020. Continuous R&D to improve the efficiency and speed of chromatography systems is anticipated to propel the segment growth. In December 2020, Bolt Biotherapeutics conducted chromatography modeling using GoSilico ChromX simulation software to accelerate bioprocessing.
A rise in the deals and developments pertaining to chromatography systems also facilitates segment growth. For instance, in January 2021, Sartorius Stedim Biotech announced to acquire the chromatography equipment business from Novasep. This will assist Sartorius to develop novel chromatography systems which in turn will overcome efficiency issues and bottlenecks in downstream processing.
The filters segment is expected to register the fastest CAGR from 2021 to 2028. The rise in the utility of filters for viral inactivation is the key factor driving this market for downstream processing. In September 2020, a team of researchers from Pennsylvania State University analyzed the efficiency of BioEX hollow fiber and Planova 20N virus filters for the removal of viral-size particles. Such studies are anticipated to increase the adoption rate of filters for downstream processing of biologics.
The production segment dominated the market for downstream processing and generated the largest revenue share of 32.9% in 2020 owing to the wide applications of antibiotics for the treatment of several disorders. More than 700,000 people die of antibiotic-resistant bacteria annually. This leads to high demand for the development of antibiotics which, in turn, propels the market growth.
Antibodies production grew at the fastest rate owing to the rise in demand for. The launch of novel products for efficient purification of antibodies also propels segment growth. For instance, in January 2021, Cytiva launched HiScreen Fibro PrismA for process development and purification of monoclonal antibody (mAb). The product features a fiber-based Protein A platform which enables a 20-fold increase in productivity.
The purification by chromatography segment dominated the downstream processing market and accounted for the largest revenue share of 40.9% in 2020. Single-use chromatography and filtration systems are considered the gold standards in downstream bioprocessing, hence companies are engaging in business development strategies such as acquisition, merger, and agreement for expanding their chromatography portfolio.
For instance, in October 2020, Repligen Corporation entered into a definitive agreement for the acquisition of ARTeSYN Biosolutions. ARTeSYN Biosolutions is an established provider of single-use filtration and chromatography systems. The company also offers a wide product range of single-use systems for continuous manufacturing, and media/buffer preparation workflows.
Similarly, in April 2020, Sartorius AG acquired Danaher Corporation’s chromatography hardware and resins, particle validation standards and microcarriers, and single-use tangential flow filtration business. This acquisition will help the company to expand its downstream processing offerings for chromatography systems.
Solid-liquid separation is expected to witness the highest CAGR of 16.9% during the forecast period. There are several advantages of solid-liquid separation such as it is simple, cost-effective, and well suited for continuous mode manufacturing. However, high shear forces generated is a common hurdle with this technique. Therefore, to cope up with such problems, recent developments such as depth filters include multistage depth filtration, alternating tangential flow microfiltration, and tangential flow filtration methods are increasingly adopted for high cell density processes.
North America dominated the market for downstream processing with the largest revenue share of 34.6% in 2020 owing to government support for promoting bioprocess technologies, rising medical expenditure, and developed healthcare infrastructure. In addition, the region has witnessed major collaborative activities with healthcare giants that are extensively investing in the R&D of biopharmaceuticals and vaccines.
In addition, key players operating in the market for downstream processing are expanding their foothold in this region. For instance, in December 2020, Thermo Fisher Scientific Inc. announced further expansion in Europe and North America for the commercial manufacturing of medicines, vaccines, and therapies. The expansion added 15 development and cGMP commercial production lines, leveraging the company’s robust quality standards for supporting a range of manufacturing capabilities.
In Asia Pacific, the market for downstream processing is expected to register the highest growth rate of 17.3% due to the rising investments by developers and consumers in the field of biotechnology. The presence of a large population base is driving the need for advanced medical facilities for which players are keen on implementing rapid analytical methods to support in-process designing and bioprocessing.
China dominated the market share in the Asia Pacific owing to the growing biopharmaceutical industry and increasing demand for medicines and vaccines. The biopharmaceutical industry is amongst the most active economic sectors in China and is marked with continuous revolution with modern biopharmaceutical equipment and process.
Sartorius Stedim Biotech S.A
Thermo Fisher Scientific Inc.
Boehringer Ingelheim International GmbH
Lonza Group Ltd
Purification by Chromatography
Middle East and Africa (MEA)
The Downstream Processing market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.
The report provides size (in terms of volume and value) of Downstream Processing market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.
This report focuses on the global Downstream Processing market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Downstream Processing market development in United States, Europe and China.
It is pertinent to consider that in a volatile global economy, we haven’t just conducted Downstream Processing market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.
In terms of production side, this report researches the Downstream Processing capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.
In terms of consumption side, this report focuses on the consumption of Downstream Processing by regions (countries) and application.
Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Downstream Processing market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.
With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Downstream Processing market companies.
Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Downstream Processing market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.
The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.
Overall, this is an in-depth research report specifically for the Downstream Processing industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.
The Downstream Processing market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Downstream Processing market.
Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Downstream Processing market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.
Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Downstream Processing market. These factors have benefited the growth of the global market for Downstream Processing. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.
New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Downstream Processing. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).
In this study, the years considered to estimate the market size of Downstream Processing are as follows:
Reasons to Purchase this Report:
- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.
This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.
Market Size Estimation
Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).
The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.
Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.
All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.
Market Breakdown and Data Triangulation
After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.
Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.
In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.
The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.
The study objectives of this report are:
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