Downstream Processing Market (By Product: Chromatography Columns & Resins, Filters, Membrane Absorbers, Single-use Products, and Others; By Technique: Purification, Solid-Liquid Separation, and Clarification/Concentration; By Application; By End User) - Global Industry Analysis, Size, Share, Growth, Trends, Revenue, Regional Outlook and Forecast 2021-2030

Published Date : Jul 2021 | No. of Pages : 150+ Pages | Category : Healthcare

The global downstream processing market value reached at US$ 6.8 Bn in 2020 and predicted to surpass around US$ 24.2 billion by 2030, expanding at a rapid pace from 2020 to 2030.

Downstream processing is a series of events that is carried out in the pharmaceutical industry for the recovery and purification of the desired yield. These procedures play a vital role in biopharmaceutical production, as these procedures help companies to reach optimum levels of products at low cost of production.

Downstream processing involves several procedures such as cell separation, filtration, product recovery, product extraction, purification, and treatment of product by chemical, physical, and biological means. Downstream processing is an integral step in the production of various biological and pharmaceutical products such as vaccines, recombinant proteins/enzymes, antibiotics, antibodies, hormones, diagnostic enzymes, industrial enzymes, natural fragrance, and flavor compounds.

The expansion of the global downstream processing market can be attributed to rise in the demand for vaccines for COVID-19, introduction of new products and solutions for microbial fermentation, and continuous expansion of biopharmaceutical and biotechnology industries.  However, limitations & constraints in producing humanized peptides and stringent rules and regulations for validating filtration products are likely to restrain the downstream processing market in the short-term.

Consistent Expansion of Biopharmaceutical and Biotechnology Industries to Boost Downstream Processing Market

Expansion of the biopharmaceutical industry can be attributed to high efficacy and fewer side effects, which these drugs offer. Similarly, the biotechnology industry has been expanding significantly, owing to continuous evolution in available technologies and introduction of new ones.

Major pharmaceutical companies have been focusing on the biopharma industry over the past few years by investing in biotech R&D, which has resulted in better returns as compared to the average of the pharmaceutical industry in general.

Single-use Systems Help Speed up Product Recovery, Simplify Downstream Operations

Single-use systems are helping to achieve low production quantities, improved target recovery, and increased conformation times. Membrane adsorbers and single-use chromatography columns are being highly publicized in the downstream processing market. This is evident since research laboratories are accustomed to disposable materials, such as pipettes and tubing, and has led to the acceptance of single-use filters, chromatography columns, and membrane adsorbers.

New technologies such as spin-filters for product concentration or diafiltration are also helping to simplify downstream operations. This explains why the downstream processing market is projected to advance at a rapid pace during the forecast period. Single-use systems are helping to speed up product recovery for initial target design & confirmation and tests in animals.

Foam Fractionation Methods Help Evaluate Separation Efficiency of Biochemical Components

New process concepts and innovations in foam fractionation methods are grabbing the attention of stakeholders in the downstream processing market. For instance, Lehrstuhl für Anlagen- und Prozesstechnik - a university department in Garching bei München, Germany, is gaining recognition for its Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR) as alternative technique to classical ATPE. CPC is gaining popularity as a new technology for enzymatic reactions combined with simultaneous product separation.

Foam fractionation methods involve the evaluation of separation efficiency for biochemical components from complex fermentation broth. Companies in the downstream processing market are investigating hydrodynamic and adsorption kinetics in foam.

Advancements in Acoustophoresis Lead to Innovations in Ultrasonic Cell Separation

Innovations in technology and equipment have benefitted downstream processing. Advancements in acoustophoresis i.e. ultrasonic cell separation and high precision microfluidics for label-free cell selection are acting as key drivers for growth in the downstream processing market. Companies are gaining a strong research base in rapid gene delivery and in-line cell washing, which leads to significant productivity gains.

In order to accomplish cell separation on a clinical blood sample, companies in the downstream processing market are partnering with researchers to develop systems that perform acoustophoresis in high performance microfluidic devices. Such systems are bypassing the need for centrifugation. In the gene therapy space, companies are increasing efforts to develop microfluidic transduction modules that can co-localize viral vector around cells.

Report Highlights

In terms of technique, the global downstream processing market has been classified into solid-liquid separation, purification, and concentration & others. The purification segment dominated the global market in 2019, and the trend is projected to continue during the forecast period. Wide adoption of technologically advanced purification techniques, increase in volume of biological products, and significant rise in the demand for biological products are expected to drive the segment during the forecast period.

Based on product, the global downstream processing market has been divided into chromatography columns & resins, filters, membrane absorbers, single-use products, and others. The chromatography columns & resins segment held a prominent share of the global market in 2019, and the trend is anticipated to continue during the forecast period. Chromatography is performed for the purification of product of interest and its separation from broth. Chromatography comprises systems and columns. Majority of the segment’s revenue is driven by the recurrent usage of chromatography resins in the purification of the desired yield in downstream processing.

In terms of application, the global downstream processing market has been divided into monoclonal antibody production, vaccine production, insulin production, immunoglobulin production, erythropoietin production, and others. The monoclonal antibody segment accounted for a notable share of the market in 2019, and the trend is anticipated to continue during the forecast period.

Currently, therapeutic monoclonal antibodies are witnessing an expansion phase of its industry lifecycle. The development of newer monoclonal antibodies for the treatment of varied chronic medical conditions with unmet medical needs is fueling the segment. As of January 2021, more than 100 monoclonal antibodies have been approved for therapeutic use in humans, and around 21 monoclonal antibodies are in regulatory review in Europe and the U.S.

Based on end user, the global downstream processing market has been classified into biopharmaceutical manufacturers and contract manufacturing organizations. The biopharmaceutical manufacturers segment dominated the global market in 2019. The segment is projected to gain market share by the end of 2030. The expansion of the segment can be attributed to high clinical R&D and production budgets, large number of biopharmaceutical players, technical expertise, and a well-developed infrastructure.

The global downstream processing market has been divided into five major regions: North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominated the global downstream processing market in 2020, followed by Europe. Well-established biopharmaceutical industry, high clinical research & development budgets in North America, and rise in demand for biologic therapeutic products in the U.S. are factors driving the downstream processing market in North America.

The market in Asia Pacific is projected to expand at a significant CAGR during the forecast period, owing to a large patient pool of chronic diseases and infections in India, China, Australia, and New Zealand, rise in per capita healthcare expenditure, rapid expansion of the biopharmaceutical industry in China and India, and increase in access to healthcare in the region.

The market in Latin America and Middle East & Africa is anticipated to expand at a moderate pace during the forecast period.

Key Players

The global downstream processing market is consolidated in terms of number of players. A few number of players account for significant share of the global market. Key players operating in the global downstream processing market include Danaher Corporation, Merck KGaA, Sartoris Stedim Biotech S.A., Thermo Fisher Scientific Inc., 3M Company, Lonza Group, Eppendorf AG, and Boehringer Ingelheim International GmbH.

Market Segmentation

By Technique

  • Purification
  • Solid-Liquid Separation
  • Clarification/Concentration

By Product

  • Chromatography Columns & Resins
  • Filters
  • Membrane Absorbers
  • Single-use product
  • Polypropylene
  • Others

By Application

  • Monoclonal Antibody Production
  • Vaccine Production
  • Insulin Production
  • Immunoglobulin Production
  • Erythropoietin Production
  • Others

By End User

  • Biopharmaceutical Manufacturers
  • Contract Research Organizations

By Region

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • Australia & New Zealand
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • GCC Countries
    • South Africa
    • Rest of Middle East & Africa

The Downstream processing market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Downstream processing market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Downstream processing market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Downstream processing market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Downstream processing market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Downstream processing capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Downstream processing by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Downstream processing market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Downstream processing market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Downstream processing market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Downstream processing industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

Downstream processing market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Downstream processing market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Downstream processing market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Downstream processing market. These factors have benefited the growth of the global market for Downstream processing. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Downstream processing. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

Major Key Points Covered in Report:

Executive Summary: It includes key trends of the downstream processing market related to products, applications, and other crucial factors. It also provides analysis of the competitive landscape and CAGR and market size of the downstream processing market based on production and revenue.

Production and Consumption by Region: It covers all regional markets to which the research study relates. Prices and key players in addition to production and consumption in each regional market are discussed.

Key Players: Here, the report throws light on financial ratios, pricing structure, production cost, gross profit, sales volume, revenue, and gross margin of leading and prominent companies competing in the Downstream processing market.

Market Segments: This part of the report discusses about product, application and other segments of the downstream processing market based on market share, CAGR, market size, and various other factors.

Research Methodology: This section discusses about the research methodology and approach used to prepare the report. It covers data triangulation, market breakdown, market size estimation, and research design and/or programs.

In this study, the years considered to estimate the market size of Downstream processing are as follows:

  • History Year: 2017-2020
  • Base Year: 2020
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies

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