Gene Delivery Technologies Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2030

Published Date : Feb 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global Gene Delivery Technologies market size is expected to be worth around US$ 8.9 billion by 2030, according to a new report by Vision Research Reports.

The global Gene Delivery Technologies market size was valued at US$ 2.6 billion in 2020 and is anticipated to grow at a CAGR of 15.5% during forecast period 2021 to 2030.

Growth Factors

Technological advancements in viral vectors, a growing pipeline of advanced therapies, and a rising number of regulatory approvals for advance therapy products are some key driving forces of the market.

Several novel tools are being introduced for genetic alterations that have facilitated the scientific community to delineate the disease intricacies at the genomic level, leading to the emergence of novel gene delivery approaches. Furthermore, ongoing research to develop clinically relevant vectors including viral and non-viral vectors to combat chronic illnesses such as cancer, Alzheimer’s, and others through advanced therapies is spurring the market revenue.

An increase in investment and financing in the space to support the research, development, and manufacturing of various modes of gene transfer further accelerates the revenue growth. Currently, around 70% of gene and cell therapy programs are based on viral vectors leading to organic revenue growth for biological delivery technologies. The operating players are investing significantly to scale up their viral vector manufacturing capability and meet the growing demand.

Report Highlights

The biological vectors segment dominated the market for gene delivery technologies and accounted for the largest revenue share of 58.0% in 2020 owing to the huge success of Kymriah and Yescarta. Viral-vectors have received great attention since the approval of the first viral vector-based gene therapy products. The exponential increase in the number of viral vectors-based R&D programs has substantiated the acceptance of viral vectors are the key delivery mode amongst end-users.

However, several clinical challenges associated with viral systems have spurred the usage of chemical methods. Chemical gene delivery technologies such as polyethyleneimine (PEI) and polyamidoamine dendrimers are recognized as an alternative to viral gene systems for their ability in combating challenges associated with the viral systems.

The lowest penetration of the physical method is their relatively lower transfection efficiency as compared to the biological and chemical methods. Low cell viability is another major shortcoming of electroporation-based physical methods. Nonetheless, these drawbacks create opportunities for the market players striving to gain revenue share by addressing the high transfection efficiency and cell viability related issues in this segment.

The gene therapy segment dominated the gene delivery technologies market and captured the maximum revenue share of 33.0% in 2020. The growing acceptance of gene-based therapies and the consequent increase in the number of clinical research initiatives have fueled the revenue generation in this segment. Increasing approval of gene therapy products across the globe has also accelerated the segment growth.

The second-generation DNA vaccines exhibit the potential to induce more-potent humoral and cellular responses. This has facilitated the investigation of this approach of disease management in both therapeutic and preventative arenas. This is anticipated to drive the uptake of gene editing tools for vaccine development.

This segment is also expected to be benefitted significantly from the recent outbreak of SARS-CoV-2. As of August 2020, nearly 25 research groups are working towards the development of viral vector-based vaccines to contain the spread of SARS-CoV-2 infection. Similarly, around 20 research teams are aiming to explore genetic instructions for the development of nucleic acid vaccines.

With a revenue share of 41.0%, the ex vivo method dominated the market for gene delivery technologies in 2020 owing to its several advantages such as the ability to assess transduction efficiency prior to implantation of cells back into the patient and less immunogenic responses. Also, it offers high transduction efficiency leading to its high usage in research settings.

On the contrary, although in vivo gene therapy is the preferred choice of gene transduction, this mode poses challenges in cases where highly targeted delivery is required. Errors in targeted delivery result in an immune response, thus less penetration of this segment in the market for gene delivery technologies.

However, scientists are making focused efforts to accelerate R&D in this segment. For instance, in March 2020, a U.S.-based Oregon Health and Science University deployed the gene-editing tool Crispr-Cas9 to edit DNA for the treatment of a genetic form of blindness inside the human body for the first time. Such developments are expected to result in the lucrative growth of this segment.

North America dominated the market for gene delivery technologies and accounted for the largest revenue share of 39.4% in 2020. A substantial number of clinical trials are underway to assess the efficacy and safety of gene therapies as a viable treatment for cancer, genetic conditions, and HIV/AIDS in the U.S. Furthermore, a significant number of major companies that are engaged in the supply and commercialization of gene delivery technologies are headquartered in the U.S. These factors have contributed to the dominance of the region in the market for gene delivery technologies.

Multiple new collaborative research and innovation projects were introduced as part of Horizon 2020 calls. The project covers viral vector-based gene therapy trials for rare conditions. This is expected to drive the adoption of gene delivery technologies across the European nations. On the other hand, Asia Pacific countries are emerging as strong contenders in this space.

Key Players

  • Thermo Fisher Scientific, Inc.

  • QIAGEN

  • Horizon Discovery Group Co.

  • OriGene Technologies, Inc.

  • Oxford Biomedica

  • SignaGen Laboratories

  • Vectalys

  • Takara Bio Inc.

  • Bio-Rad Laboratories, Inc.

  • System Biosciences llc

  • Promega Corporation

  • Hoffmann-La Roche AG

  • Sirion-Biotech GmbH

  • Catalent Inc.

Market Segmentation

  • Mode Outlook

      • Biological

      • Adenovirus

      • Retrovirus

      • AAV

      • Lentivirus

      • Other viruses

      • Non-viral

    • Chemical

    • Physical

  • Application Outlook 

    • Gene Therapy

    • Cell Therapy

    • Vaccines

    • Research

  • Method Outlook 

    • Ex vivo

    • In vivo

    • In vitro

  • Regional Outlook 

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

      • France

      • Italy

      • Spain

    • Asia Pacific

      • Japan

      • China

      • India

      • Australia

      • South Korea

    • Latin America

      • Brazil

      • Mexico

    • Middle East Africa (MEA)

      • South Africa

      • Saudi Arabia

The Gene Delivery Technologies market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Gene Delivery Technologies market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Gene Delivery Technologies market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Gene Delivery Technologies market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Gene Delivery Technologies market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Gene Delivery Technologies capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Gene Delivery Technologies by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Gene Delivery Technologies market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Gene Delivery Technologies market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Gene Delivery Technologies market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Gene Delivery Technologies industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The Gene Delivery Technologies market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Gene Delivery Technologies market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Gene Delivery Technologies market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Gene Delivery Technologies market. These factors have benefited the growth of the global market for Gene Delivery Technologies. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Gene Delivery Technologies. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Gene Delivery Technologies are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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