Gene Expression Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2030

Published Date : Mar 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global Gene Expression market size is expected to be worth around US$ 29.4 billion by 2030, according to a new report by Vision Research Reports.

The global Gene Expression market size was valued at US$ 9.07 billion in 2020 and is anticipated to grow at a CAGR of 9.96% during forecast period 2021 to 2030.

Growth Factors

Rise in investments for the development of alternative drug discovery approaches coupled with an increase in research activities for genetic studies is expected to drive the global market.

A rise in awareness about the potential application of genetic studies has led to an increase in investments for the development and launch of novel products. For instance, in August 2020, Lexogen GmbH launched the QuantSeq-Pool Sample-Barcoded 3’ mRNA-Seq Library Prep Kit to expedite multiplexing capacities during gene expression profiling. The company’s new QuantSeq-Pool kit also facilitates the sequencing of up to 36,864 RNA samples in parallel, thereby reducing cost and time. 

Furthermore, the decrease in cost associated with sequencing posed as a major driver in the last few years. According to the National Human Genome Research Institute (NHGRI), the cost of sequencing per genome reduced from USD 46.77 thousand in 2010 to USD 0.689 thousand in 2020. This dramatic 98.5% decline in sequencing costs within a decade has increased research involving genomic expression profiling studies.

Report Highlights

The cDNA synthesis & conversion process segment led the market with a revenue share of 27.06% in 2020 owing to the availability of a wide range of kits for cDNA synthesis to match the research needs pertaining to optimal reaction temperature, the number of reactions, and sample size. In addition, a rise in product launches of cDNA synthesis and library preparation kits is anticipated to propel the segment growth.

For instance, in February 2021, SeqWell launched the plexWell Single Cell Rapid Kit for the preparation of libraries for single-cell RNA sequencing. The product has brought significant enhancements to the Smart-seq2 method, which involves amplification and synthesis of cDNA. It also helps in the reduction of normalization and quality control burden by 75%.

The data analysis & interpretation segment is expected to register the fastest CAGR over the forecast period. Companies compete to provide the best data analytics and interpretation results for gene exp. arrays. For instance, in June 2020, Illumina acquired BlueBee, a cloud-based software company, to enhance Illumina’s capabilities for interpretation and analysis of data delivered by its sequencing systems.

High investments in cancer-related research and the need for better interpretation software for cancer gene exp. would accelerate the segment growth. Various approaches and algorithms are developed focusing on gene exp. studies for such complex diseases. For instance, projective clustering techniques and ensemble techniques are reported to be used for the integration of cancer gene exp. data.

The kits & reagents product segment dominated the global gene expression market in 2020 with a revenue share of over 74%. The large share of the segment is attributed to the presence of a high number of companies offering different types of kits & reagents for gene exp. For instance, Agilent Technologies, Inc. offers an extensive range of gene exp. microarray kits & reagents. Furthermore, the introduction of advanced products designed for specific applications drives the segment growth.

In May 2020, CARTANA, a biotechnology company based in Sweden, launched a range of in situ sequencing kits to perform high-throughput mapping in single cells. This product is 5 to 10 times more sensitive than the company’s cDNA-based kits. Therefore, the launch of such products increases the utilization of kits & reagents.

The DNA chip/microarray segment is estimated to register the fastest CAGR from 2021 to 2028 owing to the rise in utilization of DNA microarrays for analysis of gene exp. Microarrays facilitate high-throughput gene exp. analysis of large genome sets. Moreover, technological advancements in this area have increased the application of microarrays in diagnostics, drug discovery, biomedicine, and other biotechnology fields.

The High-Plex capacity segment accounted for the largest revenue share of 64.2% in 2020 and is projected to retain the dominant position by growing at the fastest CAGR over the forecast period. A rise in the adoption of gene exp. analysis for multiple genomic studies is a key factor driving the segment growth. Moreover, the presence of market participants, such as ThermoFisher Scientific, that offer high-throughput and fast solutions for multiplexed gene exp. quantitation boosts the segment development.

For instance, Illumina, Inc. offers TruSeq Targeted RNA Exp. Library Prep Kits for customized mid- to high-plex profiling. Furthermore, high-plex analysis reduces hands-on time when compared to qPCR and other conventional technologies. The technique is also highly accurate and simple as it eliminates the requirement of upfront probe validation. The development of spatially resolved, multiplexed digital characterization systems further enhances the segment growth.

The RNA exp. technique segment dominated the market with a revenue share of over 41% in 2020. Acceleration of high-throughput technologies, such as cDNA microarray and RNA sequencing (RNA-seq), often replaces preceding techniques. Hence, technological advances in RNA exp. tools and techniques coupled with the availability of a range of products to meet different research needs are anticipated to increase the adoption of these techniques for gene exp. analysis.

DNA microarrays and PCR techniques are the major contributors to the large share of this segment as these techniques have a significant adoption rate and have helped researchers and biologists to study expressions of various genes and microorganisms. Microarrays are used to obtain wide coverage of genome expression. Thus, increased genomic research that studies the effects of mutation in biological systems or investigates changes in exp. profiling of the whole genome is anticipated to increase the adoption of DNA microarrays.

RT-PCR has brought revolutionary changes to gene exp. studies with its high efficiency and speed. Moreover, advanced versions of PCR, such as digital PCR and qPCR, have applications in differential or comparative exp. analysis. These improvements in the PCR technology have increased the adoption of PCR for RNA exp. analysis.

The drug discovery & development segment accounted for the largest revenue share of over 41% in 2020. A rise in the analysis of gene exp. profiles of SARS-CoV-2 receptors for in silico drug discovery for COVID-19 is a high-impact rendering driver for the segment. An August 2020 research study used gene exp. profiles to explore major functions of Angiotensin-converting enzyme 2 (ACE2)-correlated genes.

Gene exp. profiles were obtained from Genotype-Tissue Exp., Gene Exp. Omnibus, The Cancer Genome Atlas, and other public datasets. As ACE2 is the main cell receptor for SARS-CoV-2 and SARS-CoV, such type of co-expression analysis helped with the evaluation of drugs for Covid-19 treatment.

A rise in demand for early and accurate diagnostic tests for complex disorders is expected to drive the clinical diagnostics application segment with the fastest CAGR from 2021 to 2028. The use of RNA exp. in clinical diagnostics to provide an early and accurate diagnosis of the Early-Onset Infection (EOI) and other rare genetic conditions in preterm infants drives segment growth.

North America held the largest revenue share of more than 45% in 2020. This can be attributed to the presence of a significant number of key players, such as Thermo Fisher Scientific, in the region.

Key players are continuously involved in extensive R&D to develop new technology & methods that involve gene exp. analysis. For instance, Decibel Therapeutics, Inc., a U.S.-based biotechnology company, collaborated with Regeneron Pharmaceuticals to develop DB-OTO. DB-OTO is a preclinical stage gene therapy candidate that is being developed by using an exclusive, cell-selective promoter to regulate gene exp. in hair cells of the cochlea. The product is expected to enter the clinical phase by 2022.

Asia Pacific is estimated to be the fastest-growing regional market from 2021 to 2028 owing to the rising interest of dominant players in emerging markets, such as China and India. Sequencing and array technologies are widely adopted in this region owing to increased genomic and gene-related studies. Japan maintains its data repositories, such as DNA Data Bank of Japan (DDBJ) and Kyoto Encyclopedia of Genes and Genomes. These provide tools, such as GenomeNet Bioinformatics Tools, for sequencing, genome, and chemical analysis.

Key Players

  • QIAGEN

  • Quest Diagnostics, Inc.

  • F. Hoffmann-La Roche Ltd.

  • Illumina, Inc.

  • PerkinElmer, Inc.

  • Bio-Rad Laboratories

  • Thermo Fisher Scientific, Inc.

  • Agilent Technologies

  • GE Healthcare

  • Promega Corp.

  • Luminex Corp.

  • Takara Bio, Inc.

  • Danaher Corp.

  • ELITechGroup

  • AutoGenomics

  • Biocartis NV

  • IntegraGen

  • Interpace Biosciences, Inc.

  • Fluidigm Corp.

Market Segmentation

  • Process Outlook

    • Sample Collection

    • Purification

    • cDNA Synthesis & Conversion

    • PCR Analysis

    • Data Analysis & Interpretation

  • Product Outlook

    • Kits & Reagents

    • DNA Chip/Microarray

    • Others

  • Capacity Outlook 

    • Low- to Mid-Plex

    • High-Plex

  • Technique Outlook 

    • RNA Exp.

      • Northern Blotting

      • DNA Microarrays

      • PCR Techniques

      • RNA-Seq

    • Promoter Analysis

      • In vitro Transcription/Nuclear Run-On Assays

      • Gel Shift Assays

      • Chromatin Immunoprecipitation (ChIP) Assays

    • Protein Exp. & Posttranslational Modification Analysis

      • Western Blotting

      • 2-D Gel Electrophoresis

      • Immunoassays

      • Mass Spectrometry

  • Application Outlook 

    • Drug Discovery & Development

    • Clinical Diagnostics

      • RNA Exp.

      • Other Techniques

    • Biotechnology & Microbiology

    • Others

  • Regional Outlook

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • France

      • U.K.

      • Italy

      • Spain

    • Asia Pacific

      • Japan

      • China

      • India

      • Australia

      • South Korea

    • Latin America

      • Brazil

      • Mexico

    • Middle East Africa (MEA)

      • South Africa

      • Saudi Arabia

The Gene Expression market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Gene Expression market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Gene Expression market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Gene Expression market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Gene Expression market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Gene Expression capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Gene Expression by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Gene Expression market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Gene Expression market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Gene Expression market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Gene Expression industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The Gene Expression market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Gene Expression market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Gene Expression market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Gene Expression market. These factors have benefited the growth of the global market for Gene Expression. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Gene Expression. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Gene Expression are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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