Heparin Market Size, Share, Growth, Trends, Consumption, Revenue, Company Analysis, Regional Insights and Forecast 2021-2030

Published Date : Nov 2020 | No. of Pages : 200 Pages | Category : Healthcare

The global heparin market size was valued US$ 11.3 Bn in 2020 and expected to reach US$ 20.1 billion by 2030 with a CAGR of 7.3% from 2021 to 2030.

Heparin is an anti-coagulant generally derived from the bovine and porcine tissue. Besides, it is also extracted and characterized from whales, humans, mice, clams, shrimps, and fresh water mussel.

Heparin is used in the treatment of clots, and the global market is impacted by various factors such as the high incidence rate of thromboembolism, advent of biosimilars, quality issues, and further research activities for introducing novel and safe heparin products. Introduction of new anti-coagulants such as rivaroxaban, dabigatran, and apixaban is detrimental for the growth of the heparin market.

North America dominated the global heparin market in 2019 and the trend is anticipated to continue during the forecast period. Some of the key growth drivers of the global heparin market include an aging population, rising incidence of cancer and its associated clotting disorders, and an increase in the number of coagulation tests during pregnancy in the past few years. The CDC reported that the medical cost associated with venous thromboembolism (VTE) treatment in the U.S. is approximately US$ 10 billion each year.

Asia Pacific is likely to be a highly lucrative market for heparin and it is expected to expand at a high CAGR during the forecast period.

Rise in incidence of coagulation and renal disorders and Increasing government initiatives for preventive health care programs to Drive Market

  • Coagulation disorders such as venous thromboembolism (VTE), which includes both deep vein thrombosis and pulmonary embolism, cause around 1.2 million deaths across the world each year. According to the CDC, an estimated 500,000 to 900,000 people are affected by VTE in the U.S. each year. Moreover, the number of deaths due to VTE in Europe is higher than deaths caused by AIDS, breast and prostate cancers, and highway accidents collectively.
  • A study published by Deutsches Arzteblatt International in 2013 revealed that the annual incidence rate of diagnosed VTE is 150 to 200 cases per 100,000 in Germany. In an acute phase, the mortality rate of pulmonary embolism (PE) in Germany is approximately 7% to 11% i.e., about 40,000 deaths because of PE in the country each year. The statistics above clearly indicate demand for safe, reliable, and affordable anticoagulants.
  • According to the CDC, one out of every three adult citizens in the U.S. suffers from hypertension, which is considered to be the second-largest risk factor for stroke, which is caused by a blood clot. Medication and lifestyle changes are effective and affordable; however, the overall rate of blood pressure control remains suboptimal. 'Million Hearts' is an initiative led by the U.S. Department of Health & Human Services and co-led by CDC and the Centers for Medicare and Medicaid Services. The committee aligns and coordinates its activities in order to achieve hypertension control rates above 70% through electronic health records, innovations in health information technology, and patient communication.

Low Molecular Weight Heparin Segment to Dominate Market

  • Based on product, the global heparin market has been divided into unfractionated heparin, low molecular weight heparin (LMWH), and ultra-low molecular weight heparin (ULMWH).
  • Majority of the branded LMWH drugs in the global heparin market have gone off patent, thereby offering market access to generic manufacturers. A generic/biosimilar version of branded LMWH should be a replica with no structural alterations. There are two FDA-approved biosimilar products of Paris-based Sanofi S.A.'s Lovenox (enoxaparin), but none in Europe. Currently, the biosimilars market for LMWHs is driven by the U.S. as products under approval were considered generics and not biosimilars. This led to rapid approval of ANDA filings.
  • However, Ultra-low Molecular Weight Heparin (ULMWH) is expected to grow with the highest CAGR in the forecast period. ULMWHs are structurally similar to LMWHs with high anti-Xa and low anti-IIa activities, which leads to higher absorption and anticoagulant activity compared to LMWH. This is expected to propel the ULMWH segment throughout the forecast period.

Bovine to be Highly Lucrative Segment

  • In terms of source, the global heparin market has been classified into bovine and porcine.
  • Rise in demand for heparin to treat or prevent certain heart, blood vessel, and lung conditions is expected to fuel the porcine during the forecast period. However, Increase in demand in the emerging markets such as China, India, and Brazil is expected to drive the bovine during the forecast period

Parenteral Segment to Dominate Market

  • Based on formulation, the global heparin market has been divided into oral and parenteral.
  • Parenteral route is dominated the market in 2018 as it protects the drug from enzymatic degradation and hydrolysis. Unfractionated heparin and low molecular weight heparin are the most commonly used pharmacological agents in hospitals. The oral administration of unfractionated heparin (UFH) is inconvenient for patients. UFH needs to be administered parenterally.

North America to Dominate Global Market

  • In terms of region, the global heparin market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominated the global heparin market in 2018, followed by Europe.
  • High market share held by the North America region is attributable to technological developments in the production of heparin and the growing pharmaceutical industry in North America. The market in the region is projected to expand in the near future, owing to increase in the demand for heparin from patients suffering from deep vein thrombosis (DVT)
  • The Heparin market in Asia Pacific is anticipated to expand at a high CAGR from 2019 to 2027. This is primarily attributable to the increasing patient population and growing incidence of cancer and other chronic diseases in the region, which have led to increase in the demand for heparin products.

Competitive Landscape

  • The global Heparin market is fragmented in terms of number of players. Key players in the global market include Dr. Reddy’s Laboratories Ltd., Teva Pharmaceutical Industries Ltd., Fresenius SE & Co. KGaA, Sanofi,  Pfizer, Inc., LEO Pharma A/S, Aspen, Baxter International Inc., B. Braun Melsungen AG, Syntex S.A, among others

The global heparin market has been segmented as follows:

By Product

    • Low Molecular Weight Heparin (LMWH)
    • Ultra-low Molecular Weight Heparin (ULMWH)
    • Unfractionated Heparin (UFH)

By Source

    • Bovine
    • Porcine

By Formulation

    • Oral
    • Parenteral

By Region

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • U.K.
    • France
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific          
    • China
    • India
    • Japan
    • Australia & New Zealand
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • GCC Countries
    • South Africa
    • Rest of Middle East & Africa

Scope of Report

The Heparin market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Heparin market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Heparin market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Heparin market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Heparin market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Heparin capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Heparin by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Heparin market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Heparin market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Heparin market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Heparin industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

Heparin market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Heparin market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Heparin market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Heparin market. These factors have benefited the growth of the global market for Heparin. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Heparin. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Heparin are as follows:

  • History Year: 2017-2020
  • Base Year: 2020
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

Table of Contents

1. Preface

    1.1. Market Definition and Scope

    1.2. Market Segmentation

    1.3. Key Research Objectives

    1.4. Research Highlights

2. Assumptions and Research Methodology

3. Executive Summary: Global Heparin Market

4. Market Overview

    4.1. Introduction

        4.1.1. Product Definition

        4.1.2. Industry Evolution / Developments

    4.2. Overview

    4.3. Market Dynamics

        4.3.1. Drivers

        4.3.2. Restraints

        4.3.3. Opportunities

    4.4. Global Heparin Market Analysis and Forecast, 2017–2030

        4.4.1. Market Revenue Projections (US$ Mn)

5. Key Insights

    5.1. Market Strategies adopted by Top Players

    5.2. Snapshot – Brand Analysis

    5.3. Porter’s Five Forces Analysis

6. Global Heparin Market Analysis and Forecast, by Product

    6.1. Introduction & Definition

        6.1.1. Key Findings / Developments

    6.2. Global Heparin Market Value Forecast, by Product, 2017–2030

        6.2.1. Low Molecular Weight Heparin (LMWH)

        6.2.2. Ultra-low Molecular Weight Heparin (ULMWH)

        6.2.3. Unfractionated Heparin (UFH)

    6.3. Global Heparin Market Attractiveness, by Product

7. Global Heparin Market Analysis and Forecast, by Source

    7.1. Introduction & Definition

        7.1.1. Key Findings / Developments

    7.2. Global Heparin Market Value Forecast, by Source, 2017–2030

        7.2.1. Bovine

        7.2.2. Porcine

    7.3. Global Heparin Market Attractiveness, by Source

8. Global Heparin Market Analysis and Forecast, by Formulation

    8.1. Introduction & Definition

        8.1.1. Key Findings / Developments

    8.2. Global Heparin Market Value Forecast, by Formulation, 2017–2030

        8.2.1. Oral

        8.2.2. Parenteral

    8.3. Global Heparin Market Attractiveness, by Formulation

9. Global Heparin Market Analysis and Forecast, by Region

    9.1. Key Findings

    9.2. Global Heparin Market Value Forecast, by Region

        9.2.1. North America

        9.2.2. Europe

        9.2.3. Asia Pacific

        9.2.4. Latin America

        9.2.5. Middle East & Africa

    9.3. North America Heparin Market Attractiveness, by Region

10. North America Heparin Market Analysis and Forecast

    10.1. Introduction

        10.1.1. Key Findings

    10.2. North America Heparin Market Value (US$ Mn) Forecast, by Product, 2017–2030

        10.2.1. Low Molecular Weight Heparin (LMWH)

        10.2.2. Ultra-low Molecular Weight Heparin (ULMWH)

        10.2.3. Unfractionated Heparin (UFH)

    10.3. North America Heparin Market Value (US$ Mn) Forecast, by Source, 2017–2030

        10.3.1. Bovine

        10.3.2. Porcine

    10.4. North America Heparin Market Value (US$ Mn) Forecast, by Formulation, 2017–2030

        10.4.1. Oral

        10.4.2. Parenteral

    10.5. North America Heparin Market Value (US$ Mn) Forecast, by Country, 2017–2030

        10.5.1. U.S.

        10.5.2. Canada

    10.6. North America Heparin Market Attractiveness Analysis

        10.6.1. By Product

        10.6.2. By Source

        10.6.3. By Formulation

        10.6.4. By Country

11. Europe Heparin Market Analysis and Forecast

    11.1. Introduction

        11.1.1. Key Findings

    11.2. Europe Heparin Market Value (US$ Mn) Forecast, by Product, 2017–2030

        11.2.1. Low Molecular Weight Heparin (LMWH)

        11.2.2. Ultra-low Molecular Weight Heparin (ULMWH)

        11.2.3. Unfractionated Heparin (UFH)

    11.3. Europe Heparin Market Value (US$ Mn) Forecast, by Source, 2017–2030

        11.3.1. Bovine

        11.3.2. Porcine

    11.4. Europe Heparin Market Value (US$ Mn) Forecast, by Formulation, 2017–2030

        11.4.1. Oral

        11.4.2. Parenteral

    11.5. Europe Heparin Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2030

        11.5.1. Germany

        11.5.2. U.K.

        11.5.3. France

        11.5.4. Spain

        11.5.5. Italy

        11.5.6. Rest of Europe

    11.6. Europe Heparin Market Attractiveness Analysis

        11.6.1. By Product

        11.6.2. By Source

        11.6.3. By Formulation

        11.6.4. By Country/Sub-region

12. Asia Pacific Heparin Market Analysis and Forecast

    12.1. Introduction

        12.1.1. Key Findings

    12.2. Asia Pacific Heparin Market Value (US$ Mn) Forecast, by Product, 2017–2030

        12.2.1. Low Molecular Weight Heparin (LMWH)

        12.2.2. Ultra-low Molecular Weight Heparin (ULMWH)

        12.2.3. Unfractionated Heparin (UFH)

    12.3. Asia Pacific Heparin Market Value (US$ Mn) Forecast, by Source, 2017–2030

        12.3.1. Bovine

        12.3.2. Porcine

    12.4. Asia Pacific Heparin Market Value (US$ Mn) Forecast, by Formulation, 2017–2030

        12.4.1. Oral

        12.4.2. Parenteral

    12.5. Asia Pacific Heparin Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2030

        12.5.1. China

        12.5.2. Japan

        12.5.3. India

        12.5.4. Australia & New Zealand

        12.5.5. Rest of Asia Pacific

    12.6. Asia Pacific Heparin Market Attractiveness Analysis

        12.6.1. By Product

        12.6.2. By Source

        12.6.3. By Formulation

        12.6.4. By Country/Sub-region

13. Latin America Heparin Market Analysis and Forecast

    13.1. Introduction

        13.1.1. Key Findings

    13.2. Latin America Heparin Market Value (US$ Mn) Forecast, by Product, 2017–2030

        13.2.1. Low Molecular Weight Heparin (LMWH)

        13.2.2. Ultra-low Molecular Weight Heparin (ULMWH)

        13.2.3. Unfractionated Heparin (UFH)

    13.3. Latin America Heparin Market Value (US$ Mn) Forecast, by Source, 2017–2030

        13.3.1. Bovine

        13.3.2. Porcine

    13.4. Latin America Heparin Market Value (US$ Mn) Forecast, by Formulation, 2017–2030

        13.4.1. Oral

        13.4.2. Parenteral

    13.5. Latin America Heparin Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2030

        13.5.1. Brazil

        13.5.2. Mexico

        13.5.3. Rest of Latin America Latin America

    13.6. Latin America Heparin Market Attractiveness Analysis

        13.6.1. By Product

        13.6.2. By Source

        13.6.3. By Formulation

        13.6.4. By Country/Sub-region

14. Middle East & Africa Heparin Market Analysis and Forecast

    14.1. Introduction

        14.1.1. Key Findings

    14.2. Middle East & Africa Heparin Market Value (US$ Mn) Forecast, by Product, 2017–2030

        14.2.1. Low Molecular Weight Heparin (LMWH)

        14.2.2. Ultra-low Molecular Weight Heparin (ULMWH)

        14.2.3. Unfractionated Heparin (UFH)

    14.3. Middle East & Africa Heparin Market Value (US$ Mn) Forecast, by Source, 2017–2030

        14.3.1. Bovine

        14.3.2. Porcine

    14.4. Middle East & Africa Heparin Market Value (US$ Mn) Forecast, by Formulation, 2017–2030

        14.4.1. Oral

        14.4.2. Parenteral

    14.5. Middle East & Africa Heparin Market Value (US$ Mn) Forecast, by Country/Sub-region, 2017–2030

        14.5.1. GCC Countries

        14.5.2. South Africa

        14.5.3. Rest of Middle East & Africa

    14.6. Middle East & Africa Heparin Market Attractiveness Analysis

        14.6.1. By Product

        14.6.2. By Source

        14.6.3. By Formulation

        14.6.4. By Country/Sub-region

15. Competition Landscape

    15.1. Market Player - Competition Matrix (by Tier and Size of companies)

    15.2. Market Share / Position Analysis, by Company, 2018

    15.3. Competitive Business Strategies

    15.4. Company Profiles

        15.4.1. Dr. Reddy’s Laboratories Ltd

            15.4.1.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.1.2. Growth Strategies

            15.4.1.3. SWOT Analysis

        15.4.2. Teva Pharmaceutical Industries Ltd

            15.4.2.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.2.2. Growth Strategies

            15.4.2.3. SWOT Analysis

        15.4.3. Fresenius SE & Co. KGaA

            15.4.3.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.3.2. Growth Strategies

            15.4.3.3. SWOT Analysis

        15.4.4. Sanofi

            15.4.4.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.4.2. Growth Strategies

            15.4.4.3. SWOT Analysis

        15.4.5. Pfizer, Inc.

            15.4.5.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.5.2. Growth Strategies

            15.4.5.3. SWOT Analysis

        15.4.6. LEO Pharma A/S

            15.4.6.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.6.2. Growth Strategies

            15.4.6.3. SWOT Analysis

        15.4.7. Aspen

            15.4.7.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.7.2. Growth Strategies

            15.4.7.3. SWOT Analysis

        15.4.8. Baxter International Inc.

            15.4.8.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.8.2. Growth Strategies

            15.4.8.3. SWOT Analysis

        15.4.9. B. Braun Melsungen AG

            15.4.9.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.9.2. Growth Strategies

            15.4.9.3. SWOT Analysis

        15.4.10. Syntex S.A

            15.4.10.1. Company Overview (HQ, Business Segments, Employee Strength)

            15.4.10.2. Growth Strategies

            15.4.10.3. SWOT Analysis


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