In Situ Hybridization Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2030

Published Date : Apr 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global In Situ Hybridization market size is expected to be worth around US$ 11.84 billion by 2030, according to a new report by Vision Research Reports.

The global In Situ Hybridization market size was valued at US$ 977.3 million in 2020 and is anticipated to grow at a CAGR of 17.3% during forecast period 2021 to 2030.

Growth Factors

Increasing demand for molecular diagnostic tools in clinical research and diagnosis is anticipated to fuel demand for ISH in the coming years. Real-time and automated diagnostic kits for accurate and rapid diagnosis of cytogenetic modifications is boosting the growth prospects of the market.

Market penetration of Fluorescent In Situ Hybridization (FISH) probe in cancer diagnostics is the highest in the current scenario, which is contributing to its largest revenue share. Increasing R&D pertaining to the application of ISH in genetic diseases and testing of infectious diseases is expected to drive the market in the near future. For instance, in 2016, Oxford Gene Technology expanded its portfolio of Cytocell Aquarius FISH probes for pathology.

Report Highlights

Fluorescence In Situ Hybridization (FISH) held the dominant share as of 2016. The market is predominantly driven by availability of technologically advanced . Advent of 3D DNA FISH technology is considered one of the major advancements owing to which the market is likely to exhibit a strong CAGR. This technology facilitates visualization and analysis of target cells in three-dimensional aspects, thereby creating the potential for positive research outcomes.

FISH has become an indispensable technology for direct and rapid identification of single-cell microbes. Recently introduced technological advancements in FISH are web-based technologies for probe design and optimization in experiments, signal amplification strategies that are easy to implement, innovative approaches for multiplexing, and combination of extracellular staining techniques or transmission electron microscopy. These advancements are anticipated to fuel the adoption of this technology over the forecast period.

CISH is expected to witness steady growth in the coming years. Technological advancements in CISH probes have several advantages over existing technologies for diagnostics and research purposes. These benefits include limited risk of contamination as in case of Polymerase Chain Reaction (PCR), greater reagent stability, cost-efficiency, ability to test archival specimens, and simultaneous observation of tissue morphology.

Other benefits include greater storage time for samples analyzed in a research activity or diagnostic studies, which requires a longer period. In addition, advent of CISH probes has helped overcome practical limitations associated with traditional technologies. These are some of the factors contributing to the growth potential of this segment in the coming years.

Major benefits associated with DNA probes include rapid speed of performing assays, which has made this technique a pivotal cytogenetic diagnostic procedure. Breast cancer is one of the major factors responsible for fueling the adoption of DNA probes for clinical usage. It is the second-largest cause of cancer-related deaths and a major contributor to world mortality rates.

Growing penetration of DNA probes in infectious disease testing is boosting the growth prospects for this segment. This can be attributed to associated benefits such as high-volume testing and presence of automated devices equipped to facilitate tests with greater speed and accuracy. Increasing incidence of diseases with chromosomal aberrations such as genetic abnormalities and cancer as well as unmet diagnostic and clinical needs are expected to be high growth rendering drivers for this segment.

Instruments held the largest share in the market in 2016 owing to increase in demand from diagnostic and research laboratories. Potential benefits such as higher cost-efficiency, ease of usage, and portability have made these instruments a preferred choice for ISH among researchers and pathologists.

In addition, increase in number of collaborations among emerging players to expand their product portfolio and establish a competitive position in the market is anticipated to boost market growth. For instance, in April 2016, Agilent Technologies, Inc. and Applied Spectral Imaging announced a comarketing agreement to market Agilent’s FISH imaging systems. Major companies in the market include PerkinElmer, Inc.; Leica Biosystems Nussloch GmbH; and Thermo Fisher Scientific.

The kits and probes segment is expected to exhibit a lucrative CAGR over the forecast period. Rising incidence of target disorders such as cancer is expected to drive demand for these products. Kits and probes are an indispensable part of ISH. Owing to extensive usage in research and clinical laboratories, this segment is anticipated to exhibit strong growth in the coming years. Rising demand for sensitive, rapid, and accurate diagnostic techniques, coupled with extensive R&D for development of novel probes and increase in healthcare expenditure, is anticipated to drive the market through 2025.

The services segment is also expected to exhibit exponential growth. Increasing outsourcing to ensure high adherence to quality standards and improve operational functionalities is contributing toward the lucrative nature of this segment.

By application, the In Situ Hybridization (ISH) market is categorized into cancer, cytogenetics, developmental biology, infectious diseases, and others. Application of ISH technology in cancer accounted for the largest revenue share in 2016. This can be attributed to growing prevalence of cancer and increase in research in this sector. ISH probes act as a better alternative to potentially hazardous and costly radioactive methods used for detection and research of chromosomal alteration in tumor cells. Hence, they have attracted the attention of an increasing number of researchers and pathologists.

This technology facilitates real-time analysis and monitors the progression of chromosomal aberrations. Technological advancements, such as advent of fluorescent molecules that work in conjunction with DNA probes to enhance overall efficiency of diagnostic procedures, are boosting the growth prospects of this segment.

ISH is being increasingly used in cytogenetics to detect chromosomal abnormalities, identify chromosomes, or to determine the location of specific sequences in chromosomes. FISH plays an important role in a variety of research areas, including gene amplification, cytogenetics, and gene mapping.

This technique has further facilitated screening of the complete genome through multicolor chromosome probe techniques, including spectral karyotyping or multiplex FISH and CISH. FISH is used to identify genetic abnormalities including aneuploidy, gene fusions, translocation, deletion, and to monitor the progression of aberrations, which provides genetic disease prognosis and diagnosis.

Research and diagnostic laboratories accounted for the largest share by end use in 2016 owing to increase in applications of in diagnostics. Increasing number of research initiatives for cell research is expected to fuel the adoption of this technology in R&D labs over the forecast period. Technological advancements in the field of molecular cytology and genomics are also expected to boost the adoption as they are used for diagnosis of diseases and research. Major advantages of these tools, such as high speed of performing assays, are expected to propel the adoption of ISH in labs. Advancements in the field of molecular pathology based on ISH is also expected to propel this segment.

The Contract Research Organizations (CROs) segment is anticipated to witness lucrative growth in the coming years. Increasing trend of outsourcing molecular biology services such as flow cytometry, cytogenetics, anatomic pathology, and ISH for testing in Phase I, II, and III of clinical trials is contributing to the lucrative CAGR of CROs during the forecast period.

North America held the dominant share in the ISH market as of 2016. This can be attributed to availability of research funds and government initiatives for development of novel diagnostic tools. Europe followed North America in terms of revenue share owing to presence of government organizations such as European Diagnostic Manufacturers Association (EDMA), which that focus on development and overall growth of the IVD industry in Europe.

EDMA invests approximately EUR 1 billion every year in R&D pertaining to IVD in Europe. Moreover, MedTech Europe, which represents the medical technology industry in Europe, has received funds from National Institute for Health Research (NIHR) and National Health Services to boost the IVD industry. For instance, NIHR provided funding to four Diagnostic Evidence Cooperatives to improve IVD and aid in overall cost-effectiveness of diagnostic procedures. These initiatives were also undertaken to improve diagnosis of diseases, patient care, and efficiency. All these factors have propelled the usage of DNA, FISH, and CISH probes to improve patient diagnosis, thereby boosting the market.

The Asia Pacific market is anticipated to exhibit lucrative CAGR in the coming years. This can be attributed to rise in awareness among researchers about benefits of ISH technology in diagnostics. In addition, increase in R&D investments by governments to promote research in the field of molecular biology in this region is contributing to overall market growth. 

Global Health Innovative Technology Fund (GHIT) provided USD 200 million to the Japanese government for R&D in the healthcare industry. GHIT will aim to strengthen its collaboration with Japanese health organizations, such as Japan Agency for Medical Research and Development, Japan’s Pharmaceutical and Medical Devices Agency, Japan International Cooperation Agency, and other major healthcare companies such as Fujifilm for the introduction of innovations in IVD. This is expected to boost the ISH market during the forecast period.

Key Players

Thermo Fisher Scientific; Leica BiosystemsNussloch GmbH; BIOVIEW; Agilent Technologies; Merck KGaA; PerkinElmer, Inc.; Bio-Rad Laboratories, Inc.; NeoGenomics Laboratories, Inc.; Advanced Cell Diagnostics, Inc.; and Oxford Gene Technology.

Market Segmentation

  • Technology Outlook

    • Fluorescent In Situ Hybridization (FISH)

    • Chromogenic In Situ Hybridization (CISH)

  • Probe type Outlook 

    • DNA

    • RNA

  • Product Outlook

    • Instruments

    • Kits & Probes

    • Software

    • Services

  • Application Outlook

    • Cancer

    • Cytogenetics

    • Developmental Biology

    • Infectious Diseases

    • Others

  • End-use Outlook 

    • Research & Diagnostic Laboratories

    • CROs

    • Academic Institutes

    • Others

  • Regional Outlook 

    • North America

      • U.S.

      • Canada

    • Europe

      • U.K.

      • Germany

    • Asia Pacific

      • Japan

      • China

      • India

    • Latin America

      • Brazil

      • Mexico

    • Middle East & Africa

      • South Africa

 

The In Situ Hybridization market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of In Situ Hybridization market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global In Situ Hybridization market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the In Situ Hybridization market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted In Situ Hybridization market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the In Situ Hybridization capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of In Situ Hybridization by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global In Situ Hybridization market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major In Situ Hybridization market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of In Situ Hybridization market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the In Situ Hybridization industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The In Situ Hybridization market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to In Situ Hybridization market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of In Situ Hybridization market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new In Situ Hybridization market. These factors have benefited the growth of the global market for In Situ Hybridization. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for In Situ Hybridization. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of In Situ Hybridization are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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