Kinase Inhibitors Market Size, Share, Growth, Trends, Consumption, Revenue, Company Analysis, Regional Insights and Forecast 2021-2028

Published Date : Nov 2020 | No. of Pages : 200 Pages | Category : Healthcare

According to Vision Research Reports, the global kinase inhibitors market size was valued at US$ 47 Bn in 2020 and expected to surpass around US$ 65 billion by 2028 with a CAGR of 4.3% from 2021 to 2028.

Kinase inhibitors are available in various types including non-receptor tyrosine kinase inhibitors, receptor tyrosine kinase inhibitors, multikinase inhibitors, serine/threonine kinase inhibitors, protein kinase C inhibitors, RHO kinase inhibitors, and others. Various applications of kinase inhibitors include oncology, inflammatory diseases, and others. Growth of the global kinase inhibitors market can be attributed to rise in awareness about kinase inhibitors and surge in product approvals and increase in incidence of cancer across globe.

North America dominated the global kinase inhibitors market in 2018 and the trend is anticipated to continue during the forecast period. Rise in awareness about new drugs for treatment and availability of all major companies in the region are anticipated to drive the market in North America. Asia Pacific is expected to be a highly lucrative market for kinase inhibitors, expanding at a higher CAGR during the forecast period.

Overview

  • Various types of kinase inhibitors available in the market such as non-receptor tyrosine kinase inhibitors, receptor tyrosine kinase inhibitors, multikinase inhibitors, serine/threonine kinase inhibitors, protein kinase C inhibitors, RHO kinase inhibitors, and others
  • In terms of revenue generation, the non-receptor tyrosine kinase inhibitors dominated the market. However, growth of the receptor tyrosine kinase inhibitors segment is anticipated to restrain, owing to patent expiry and introduction of generic drugs.

Drivers

  • Increase in incidence of cancer patients among population is the major cause of growth of the global kinase inhibitors market. According to the Cancer Research UK data, around 17 million new cases of cancer were reported worldwide in 2020 and around 27.5 million new cases of cancer are likely to be reported worldwide each year by 2040.
  • Expanding indications of existing and pipeline kinase inhibitors also boost the market growth. BCR-ABL TKIs, which were earlier approved for treating CML, are now indicated for treating acute lymphoblastic leukemia (ALL) and gastrointestinal tumors. Similarly, EGFR TKIs are approved for an array of indications such as pancreatic cancer, breast cancer, and non-small cell lung cancer.

Increase in Incidence of Cancer, Rise in Awareness about Kinase Inhibitors, and Surge in Product Approvals to Drive Market

Cancer has a major impact on the society across the world. It is one of the leading causes of death across the globe and is more prevalent in developed and emerging markets. According to the American Cancer Society data, over 1.7 million new cancer cases are expected to be diagnosed in 2020 in the U.S. Awareness about cancer diagnosis and treatment is being spread across the globe. Governing bodies are also taking initiatives to provide access to health care to the public. Companies are taking initiatives to launch more products for the treatment. Intense drug discovery programs have led to the development of clinically effective kinase inhibitors. Since 2001, more than 10,000 patent applications for kinase inhibitors have been filed in the U.S. alone.

AI Accelerates Drug Discovery for Fibrosis Treatment through Molecular Modeling

The innovations such as AI are transforming the market for kinase inhibitors. For instance, the U.S. biotechnology startup Insilico Medicine revealed its deep learning system that is capable of identifying potential treatments for fibrosis with the help of DDR1 (Discoidin Domain Receptor 1) kinase inhibitors.

AI is entering the kinase inhibitors market. Hence, companies should collaborate with biotechnology startups that are capable of integrating target identification with small molecule discovery through AI. Companies are increasing their efficacy in molecular modeling to accelerate drug discovery for fibrosis and other diseases.

Healthcare companies are capitalizing on generative adversarial networks (GANs) to generate novel molecular structures with specified properties. Likewise, deep learning is enabling companies with rapid identification of potent DDR1 kinase inhibitors. Thus, companies are improving their production capabilities to develop a novel drug pipeline of treatment of fibrosis with the help of AI.

Biochemistry a Key Focus Point for Development of Novel Kinase Inhibitors

Novel assays and profiling techniques are helping companies to develop improved kinase inhibitors for drug development. Discovery of new kinase inhibitors is anticipated to improve biochemical, cellular, and in vivo assays that could offer new therapeutic targets. This is important since oncology is the focus of healthcare providers in the kinase inhibitors space, and research in this field of study is projected to grow exponentially.

Companies in the kinase inhibitors market are increasing R&D to gain expertise in cell signaling for the development of new drugs. The kinase inhibitors market is continuing to grow since the market is largely consolidated with major players accounting to ~68% of the market share. However, developing novel kinase inhibitors poses as a challenge for manufacturers. Hence, manufacturers are collaborating with researchers to acquire a decision-based understanding of kinase biology, cell signaling, and its outcome in various diseases. They are increasing efforts to gain information on biochemical and biophysical assays to examine the potency and selectivity of kinase inhibitors.

Non-receptor Tyrosine Kinase Inhibitors to Witness High Demand

Based on type, the global kinase inhibitors market has been divided into non-receptor tyrosine kinase inhibitors, receptor tyrosine kinase inhibitors, multikinase inhibitors, serine/threonine kinase inhibitors, protein kinase C Inhibitors, RHO kinase inhibitors, and others. Non-receptor tyrosine kinase inhibitors is further segmented into Bruton's tyrosine kinase (BTK) inhibitors, BCR-ABL, Janus kinase (JAK) inhibitor, mesenchymal epithelial transition growth factor (c-MET), spleen tyrosine kinase (SYK) inhibitors, and others. The receptor tyrosine kinase inhibitors segment is again divided into VEGFR, PDGFR, EGFR, ALK, HER2, and others.

The non-receptor tyrosine kinase inhibitors segment dominated the global kinase inhibitors market in 2020 and the trend is likely to continue during the forecast period. Rise in approvals of different types of non-receptor tyrosine kinase inhibitors fuels the segment growth. In November 2019, FDA approved Bruton's tyrosine kinase (BTK) inhibitor zanubrutinib (Brukinsa) for patients with relapsed and refractory mantle cell lymphoma.

Oncology to be Key Application Area

In terms of application, the global kinase inhibitors market has been segmented into oncology, inflammatory diseases, and others. Oncology is further divided into lung cancer, renal cell cancer, breast cancer, and others. The oncology segment dominated the global kinase inhibitors market in 2020 and is expected to grow with the highest CAGR in the forecast period. Large number of approved drugs along with rich product pipeline for cancer treatment is anticipated to fuel the growth of the segment in the near future. Based on data from clinicaltrials.gov last updated on January 2020, over 75 kinase inhibitor drugs are in various phases of clinical trials for the application of oncology.

Rise in Number of Hospital Pharmacies to Drive Market

Based on distribution channel, the global kinase inhibitors market has been segmented into hospital pharmacies, independent pharmacies, and online pharmacies. The hospital pharmacies segment dominated the global kinase inhibitors market in terms of revenue in 2020 and the trend is projected to continue during the forecast period. Increase in number of prescription-based kinase inhibitors being dispensed through independent pharmacies and rise in number of independent pharmacies in developing countries make these pharmacies a major channel of distribution.

North America to Dominate Global Market

Geographically, the global kinase inhibitors market has been segmented into five major regions: North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominated the global kinase inhibitors market in 2020, followed by Europe. North America accounted for major share of the global kinase inhibitors market in 2020, owing to introduction of new drugs, and high prevalence of cases in countries such as the U.S.

The kinase inhibitors market in Asia Pacific is likely to expand at a higher CAGR from 2021 to 2028. Significant growth of the kinase inhibitors market in the region can be attributed to high prevalence of cancers and increase in demand for its therapeutics.

Competition Landscape

Novartis AG, Pfizer, Johnson & Johnson, AstraZeneca, and Bristol-Myers Squibb are the leading players in the global kinase inhibitors market that hold majority of the market share. The global kinase inhibitors Market is fragmented in terms of number of players. Key players in the global market include Novartis AG, Pfizer, Johnson & Johnson, AstraZeneca, Bristol-Myers Squibb, Boehringer Ingelheim International GmbH, Bayer AG, F. Hoffmann-La Roche Ltd, and Eisai Co., Ltd. New product development through robust R&D activities and merger & acquisitions are the key strategies adopted by these players to operate their business in the global kinase inhibitors market

Market Segmentation

By Type

  • Non-receptor Tyrosine Kinase Inhibitors
      • Bruton's Tyrosine Kinase (BTK) Inhibitors
      • BCR-ABL
      • Janus Kinase (JAK) Inhibitor
      • Mesenchymal Epithelial Transition Growth Factor (c-MET)
      • Spleen Tyrosine Kinase (SYK) Inhibitors
      • Others
  • Receptor Tyrosine Kinase Inhibitors
      • VEGFR
      • PDGFR
      • EGFR
      • ALK
      • HER2
      • Others
  • Multikinase Inhibitors
  • Serine/Threonine Kinase Inhibitors
  • Protein Kinase C Inhibitors
  • RHO Kinase Inhibitors
  • Others

By Application 

    • Oncology
      • Lung Cancer
      • Renal cell cancer
      • Breast Cancer
      • Others
    • Inflammatory Diseases
    • Others

By Distribution Channel

  • Hospital Pharmacies
  • Independent Pharmacies
  • Online Pharmacies

By Region

    • North America
      • U.S.
      • Canada
    • Europe
      • Germany
      • U.K.
      • France
      • Italy
      • Spain
      • Rest of Europe
    • Asia Pacific          
      • China
      • India
      • Japan
      • Australia & New Zealand
      • Rest of Asia Pacific
    • Latin America
      • Brazil
      • Mexico
      • Rest of Latin America
    • Middle East & Africa
      • GCC Countries
      • South Africa
      • Israel
      • Rest of Middle East & Africa

Report Scope

The Kinase inhibitors market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Kinase inhibitors market for the base year 2020 and the forecast between 2021 and 2028. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Kinase inhibitors market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Kinase inhibitors market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Kinase inhibitors market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Kinase inhibitors capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Kinase inhibitors by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Kinase inhibitors market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2028. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Kinase inhibitors market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Kinase inhibitors market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Kinase inhibitors industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

Kinase inhibitors market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Kinase inhibitors market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Kinase inhibitors market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Kinase inhibitors market. These factors have benefited the growth of the global market for Kinase inhibitors. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Kinase inhibitors. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Kinase inhibitors are as follows:

  • History Year: 2017-2020
  • Base Year: 2020
  • Forecast Year 2021 to 2028

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2028);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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