Large & Small-Scale Bioprocessing Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2030

Published Date : Apr 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global Large & Small-Scale Bioprocessing market size is expected to be worth around US$ xx billion by 2030, according to a new report by Vision Research Reports.

The global Large & Small-Scale Bioprocessing market size was valued at US$ 30.12 billion in 2020 and is anticipated to grow at a CAGR of xx% during forecast period 2021 to 2030.

Growth Factors

Bioprocess engineering has been effectively explored for the development of biopharmaceuticals and it has provided bio manufacturers and contract manufacturing organizations (CMO) with lucrative avenues of growth. This, in turn, is expected to attract focused efforts to bolster the market adoption of various bioprocess engineering solutions.

Biopharmaceuticals manufacturing is expected to serve as the lucrative source of revenue within the pharmaceutical industry in the coming years. Hence, with the gradual shift of the pharmaceutical industry towards biopharmaceuticals, the bioprocessing market is also expected to grow at a significant pace throughout the forecast period.

Rapid advancements in bioprocess engineering, including the evolution of contract services and single-use technology, have contributed huge success to the biopharmaceutical manufacturing industry. Emerging innovations, such as nano-biocatalysts, aimed to improve the turnaround times by enhancing enzyme activity and stability to enhance the bioproduction, thus driving revenue generation. 

Previously, only a handful of firms were able to handle the entire value chain of large-molecule bioproduction. However, in the current scenario, there are many companies in the space that are involved in the development of biologics and biosimilars owing to the technological advances in bioprocessing technology.

Driven by high demand for biopharmaceuticals, suppliers' product portfolio for biomanufacturing has become more robust. Suppliers of bioreactors and other ancillary bioprocessing equipment are undertaking endeavors to fulfill growing expectations of bio manufacturers concerning cost, space requirement, and portability.

Budgets for biomanufacturing operations are expanding in essentially all aspects. Companies are observed making significant investments in biomanufacturing-related R&D. This also includes hiring expert professionals and expansion of manufacturing capacity. These factors are expected to play a pivotal role in reshaping the bioprocessing of various products shortly.

Moreover, the introduction of high throughput process development and data analysis services enables entities to gain insight into the production process for product development and consequently optimizes the whole process. The evolution of bioremediation as a promising solution for cost-effective treatment of contaminants like heavy metals has also contributed to the enhanced adoption of bioprocessing equipment.

However, even though this market is expected to witness significant growth in the coming years, purification and stability issues regarding protein production as well as environmental concerns about the use of single-use bioprocessing equipment are expected to hamper the growth of the market to a certain extent.

Report Highlights

The bioprocessing workflow comprises three stages viz., upstream processing, fermentation, and downstream processing based on activities carried out for conversion of crude raw material to final finished product.

Product purification which is the key step in downstream processing is considered as the most challenging & crucial step and thus, demands more attention. This factor has contributed to the large share of this segment in 2016.

Moreover, any advancement in bioprocessing engineering directly affects the production yield, which in turn, positions the downstream processing segment as the center of significant attraction of several major big pharma stakeholders.

However, with the advent of single-use technology coupled with growth in mammalian titer for production, upstream processing is expected to grow at a lucrative pace throughout the forecast period. Also, technological modifications in bioreactors and fermenters are projected to accelerate revenue growth for the fermentation segment in the coming years.

Product Insights

Bioreactors accounted for a substantial share of the revenue inflow owing to the high usage rate coupled with large-scale bioproduction requirements from key industry participants. Automated cell culturing using specialized bioreactor designs holds great significance for the development of value-added products, thereby influencing growth in this segment.

The availability of a wide range of bioreactors based on the operation mode, phase-type, capacity, fluid flow type, use type, and applications is expected to boost revenue generation in this segment soon. Other products offered in this market include bags & containers, filtration assemblies, cell culture products, and bioreactors accessories.

Cell culture product is the fastest-growing segment. This is mainly attributed to the ongoing advancements in cell line development including the development of the recombinant cell line. Production of biopharmaceutical derived cell lines from mammalian cell lines is supportive of the projected growth of this segment.

Production of biopharmaceuticals & biotherapeutics captured the largest share owing to the commercial success of biologics & biosimilars for clinical use in the current scenario. Pharmacists are leveraging the wide spectrum application of bioprocess engineering to develop organism derived therapeutics, which in turn are expected to drive the growth of this segment.

Moreover, companies are involved in enhancing their manufacturing capacity for biopharmaceutical development, which in turn is expected to provide avenues of lucrative growth. Other applications of this market include microbial biomass, microbial enzymes, microbial metabolites, biofuels, bioremediation, and biorefineries.

Depending upon the volume of culture to be produced, bioprocessing carried out can be segmented into two broad categories viz; small and industrial scale. Small-scale bioreactor systems provide parallel processing and allow the evaluation of a series of experiments for bioprocess optimization by being part of upstream processing. This factor is expected to be supportive of the projected growth of small-scale bioprocessing.

Bioprocessing for pharmaceutical development at the industrial scale has held the largest share in 2016. Continuous introduction of techniques and tools to support industrial-scale bioprocessing in the market has accelerated industrial-scale bioprocessing applications.

For instance, In June 2016, GE Healthcare introduced Capto Q XP chromatography resin. These chromatography resins are strong anion exchanger used to perform purification of large-scale biomolecules on the industrial scale. Such initiatives are anticipated to positively influence the growth of this segment over the forecast period.

Concerning use type, this market offers the multiple-use type and single-use type products. Single-use product-based bioprocessing is expected to witness the fastest growth during the forecast period. It is observed that substantial demand for innovation in single-use instruments, is anticipated to drive growth in this segment soon.

The number of advantages associated with single-use products is expected to boost the adoption in this segment. The major advantage associated with single-use type includes a reduction in the additional expenses associated with assembly, cleaning, process validation, operation, and equipment qualification of multiple-use bioprocess equipment.

Multiple-use products for bioprocessing dominated the 2016 market in terms of revenue generation. Low environmental impact associated with the implementation of multiple-use instruments and one-time investment is the major factor attributed to its large share in the current market.

The presence of well-established international players in the market, which are capable of performing in-house biopharmaceutical production has led to the large share of in-house biomanufacturing in 2016.

The complexity of biologics is one of the major factors for keeping the manufacturing process in-house. Furthermore, companies are using their in-house capabilities as a strategy to maintain the secrecy of their product development processes.

However, in the future market, the outsourced model of manufacturing is expected to grow lucratively. This is due to the substantial growth in the budgets for the outsourcing of biomanufacturing.

Besides, factors such as lack of sufficient expertise, limited capacity to perform industrial-scale bioprocess applications, and cost-saving advantages associated with contract services are expected to provide potential opportunities in the outsourcing sector.

As represented in the above figure, North America is the largest regional market accounting for 27.34% of the overall market revenue share in 2016. The dominance of this region concerning revenue generation is due to focused cutting-edge R&D in biomanufacturing in the region.

Other key factors that are involved in influencing the progress of the market in this region are developed infrastructure and rising funds for bioprocessing technology. Moreover, the presence of a substantial number of biomanufacturing facilities in this region has also attributed to the large share of this segment.

However, Asia Pacific is anticipated to be the most attractive regional market space in the coming years. Several companies are outsourcing biologics manufacturing as well as clinical trials in the region which is the key factor to drive progress in this region.

Key Players

Merck KGaA (Sigma-Aldrich Co. LLC), Thermo Fisher Scientific, Inc.; Corning, Inc.; Sartorius AG; CESCO BIOENGINEERING Co., Ltd.; Bio-Process Group; Bioprocess Control AB; Eppendorf AG; Applikon Biotechnology; Lonza; PBS Biotech, Inc; Finesse; Binex Co., Ltd.; Meissner Filtration Products, Inc.; CMC Biologics; CellGenix GmbH; Boehringer-Ingelheim; Patheon; Samsung Biologics; Rentschler Biotechnologie GmbH; TOYOBO Co., Ltd, and Inno Biologics Sdn Bhd.

Market Segmentation

  • Scale Outlook 

    • Industrial Scale (Over 50,000 Litre)

    • Small scale (Less than 50,000 Litre)

  • Workflow Outlook 

    • Downstream Processing

    • Fermentation

    • Upstream Processing

  • Product Outlook 

    • Bioreactors/Fermenters

    • Cell Culture Products

    • Filtration Assemblies

    • Bioreactors Accessories

    • Bags & Containers

    • Others

  • Application Outlook 

    • Biopharmaceuticals

    • Specialty Industrial Chemicals

    • Environmental Aids

  • Use-type Outlook 

    • Multi-Use

    • Single-Use

  • Mode Outlook 

    • In-house

    • Outsourced

  • Regional Outlook 

    • North America

      • The U.S.

      • Canada

    • Europe

      • Germany

      • France

    • Asia Pacific

      • China

      • India

    • Latin America

      • Brazil

    • Middle East & Africa

      • South Africa

The Large & Small-Scale Bioprocessing market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Large & Small-Scale Bioprocessing market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Large & Small-Scale Bioprocessing market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Large & Small-Scale Bioprocessing market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Large & Small-Scale Bioprocessing market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Large & Small-Scale Bioprocessing capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Large & Small-Scale Bioprocessing by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Large & Small-Scale Bioprocessing market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Large & Small-Scale Bioprocessing market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Large & Small-Scale Bioprocessing market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Large & Small-Scale Bioprocessing industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The Large & Small-Scale Bioprocessing market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Large & Small-Scale Bioprocessing market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Large & Small-Scale Bioprocessing market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Large & Small-Scale Bioprocessing market. These factors have benefited the growth of the global market for Large & Small-Scale Bioprocessing. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Large & Small-Scale Bioprocessing. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Large & Small-Scale Bioprocessing are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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