MicroRNA Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2030

Published Date : Apr 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global MicroRNA market size is expected to be worth around US$ 5.6 billion by 2030, according to a new report by Vision Research Reports.

The global MicroRNA market size was valued at US$ 954.6  billion in 2020 and is anticipated to grow at a CAGR of 29.8% during forecast period 2021 to 2030.

Growth Factors

Extensive research activities targeted towards exploring the potential functions of microRNA (miRNA) to design novel therapeutic solutions against different diseases is set to contribute to the adoption of miRNA instruments and consumables. These studies assist in understanding the mechanism of action of the signaling pathway, further integral to develop miRNA drug candidates.

For instance, in June 2020, Munich researchers have discovered that a specific microRNA helps in preserving the integrity of the endothelium and hence reducing the risk of atherosclerosis. Robust funding in biotechnology companies offering miRNA therapeutics is further propelling the influx of miRNA companies. For instance, in February 2021, InteRNA Technologies received a funding of USD 22.46 million in a Series B funding round, led by AurorA Science, an Italian biotech investment company.

The funding will support the clinical evaluation of INT-1B3, its microRNA lead candidate for treating patients with advanced solid tumors. In addition, the grants will help in advancing proprietary preclinical drug candidates for addressing a variety of cancer indications. Moreover, microRNAs (miRNAs) can influence the expression of certain genes, which makes it a potential solution for developing future medicine. Additionally, researchers are exploring the role of micro-RNA in the management of SARS-COV-2 infection. Studies have indicated that miRNAs play a vital role in regulating innate and adaptive immune systems.

Furthermore, studies have shown that the expression of these miRNAs has a role in the host’s response against the coronavirus and other respiratory viruses. Several in-silico experimentations have displayed that miRNA interactions with SARS-CoV-1 cause upregulation of some miRNA such as miR-574-5p, miR-17, and miR-214; helping in the inhibition of viral replication. Hence, studying the changes in miRNA expressions using sequencing instruments can contribute to understanding the pathogenesis of such chronic respiratory infections.

Report Highlights

The consumables segment dominated the market for microRNA and held the largest revenue share of 59.9% in 2020. A wide range of consumables is used for miRNA profiling such as detection kits, qPCR primers, and transfection reagents among others. The high adoption of consumables as they are replaced regularly owing to their non-durable nature can be primarily attributed to segment growth. Some prominent players providing consumables include Thermo Fisher Scientific Inc.; Miltenyi Biotec; and NanoString.

Based on the instruments segment, real time PCR dominated the market in 2020, with a share of over 32.0% as it is considered as a gold standard when compared to other techniques for the detection of miRNA. It is routinely used as a reliable technique for detecting miRNA expression owing to its large dynamic range, high sequence specificity, and high sensitivity. It is used for a wide range of miRNA research applications such as miRNA profiling, validation, quantitation, and functional analysis.

NGS is expected to witness substantial growth of 18.2% during the forecast period. It is gaining popularity as it is a powerful tool for enabling systematic studies of the genome and it also provides insights for better disease understanding. In addition, next generation sequencing is integrated with several informatics tools that allow fast processing for analyzing complex miRNA sequencing data. For instance, CAP-miRSeq allows deep microRNA sequencing with preprocessing, miRNA qualification, alignment, and variant detection in the miRNA coding region. In addition, it allows rapid processing and provides easier downstream analyses and quality assessment.

Profiling, localization and quantification services dominated the market for microRNA and held the largest revenue share of over 35.0% in 2020. Increasing strategic collaboration between companies for providing microRNA profiling services can be primarily attributed to segment growth. For instance, in May 2020, Toray approved TATAA Biocenter’s microRNA profiling services on the 3D Gene microarray platform. The 3D Gene platform used for microRNA profiling has improved performance and robustness for performing and managing all workflow from sample preparation, microRNA profiling, and data analysis.

The isolation and purification segment is expected to witness the fastest CAGR of 16.9% over the forecast period owing to the growing focus on the development of new microRNA purification methods. For instance, in November 2020, researchers developed a magnetic bead-based RNA purification method which is relatively new and incorporates specific RNA isolation kits for efficient analysis of small RNA such as miRNAs. In addition, the RNA prepared using this method was found to be suitable for mRNA and miRNA expression analysis using real time PCR.

The academic and government research institutes segment dominated the market for microRNA and accounted for the largest revenue share of 54.2% in 2020. Supportive government initiatives for facilitating the research in genomics by academic and research institutes can be primarily attributed to the growth of the segment. For instance, in May 2020, the Australian government awarded a grant of around USD 21.6 million for supporting genomics research in pediatric disease and cancer. There are several projects that received grants which included studies at the University of Queensland that involve whole-genome sequencing of breast cancer patients and analyzing their gene expression.

Growing importance of microRNA for the diagnosis of several diseases such as cancer, cardiovascular diseases and infectious diseases by diagnostic labs, CROs, and hospitals is also set to contribute to market growth. Biotechnology and pharmaceutical companies such as Regulus Therapeutics, Mirna Therapeutics and miRagen Therapeutics are extensively getting involved in the development of RNA based therapeutics which can be attributed to its lucrative growth through 2021-2028. Most of the products developed by these companies have shown positive results in preclinical and early clinical trials.

The cancer segment dominated the market for microRNA and accounted for the largest revenue share of more than 33.0% in 2020. Cancer is amongst the most significant pathology that has a role of mRNA-miRNA interplay. There are several microRNA target sites that are clustered in cancer-associated genomic regions. In addition, there are tumor suppressor miRNAs which are commonly suppressed in the translation of mRNAs which encodes for oncogenes leading to inhibition of tumorigenesis and cancer development. Hence, microRNA dysregulation is extensively studied for finding a therapeutic solution for treating different cancers.

miRNAs have unprotected 5′-phosphate and 3′-hydroxy ends which makes them prone to degradation by ribonucleases, which causes them to be only expressed for a relatively short period of time hence limiting its use for treating cancer. For combating such challenges researchers are focusing on developing an efficient delivery system for microRNA. Recently, a nanoparticle delivery system is emerging as an attractive option for the targeted delivery of microRNAs. Several nanotechnology-based formulations are employed such as naturally occurring EVs, organic-based lipid nanoparticles (LNPs), gold, Polyamidoamine (PAMAM), and silica dendrimers.

The cardiovascular disease segment is expected to grow at a lucrative rate of 16.1% during the forecast period owing to the introduction of new molecular biomarkers for the early detection of cardiovascular diseases. microRNAs are attractive targets for cardiovascular therapeutics owing to several advantages such as tissue-specific expression pattern, secretion to the corresponding body fluids, and stability. In addition, there are several studies pointing the role of microRNA in cardiovascular diseases. For instance, it is involved in the regulation of blood pressure, lipoprotein metabolism, and the development of hypertension which eventually decides the progression of cardiovascular diseases.

North America dominated the microRNA (miRNA) market and accounted for the largest revenue share of 45.8% in 2020; growth in the region can be attributed to several factors such as the presence of key players, extensive R&D activities, and established research infrastructure for proteomics, genomics, and oncology. In addition, companies in the region are receiving patent approvals for their miRNA biomarkers. For instance, in May 2020, DiamiR received U.S. Patent approval for miRNA-based methods that are used for detection and monitoring brain aging. The patent covers the use of methods for quantitative analysis of miRNA present in detectable blood plasma and brain as biomarkers of brain aging.

In Asia Pacific, the market for microRNA is expected to witness the fastest growth rate of 20.6% through 2021 to 2028. The growth of the market in the region can be primarily attributed to rapid advancement in genomic studies and the adoption of new tools for supporting research endeavors. For instance, in February 2021, researchers from China identified blood microRNA (miRNA) as potential biomarkers for pyrrolizidine alkaloids induced hepatic sinusoidal obstruction syndrome (HSOS) by using microarray-based miRNA profiling. In addition, the study also involved various computational microRNA-target tools for predicting the relationship between miRNA and their target mRNA.

Key Players

  • Merck KGaA

  • Thermo Fisher Scientific, Inc.

  • Horizon Discovery Ltd.

  • Synlogic

  • QIAGEN

  • GeneCopoeia, Inc.

  • New England Biolabs

  • Quantabio

  • NanoString

  • BioGenex

  • SeqMatic LLC

  • Miltenyi Biotec

  • Sistemic Scotland Limited

  • Biodynamics Laboratory Inc.

  • OriGene Technologies, Inc.

Market Segmentation

  • Products Outlook 

    • Instruments

      • By Technology

        • Real Time PCR

        • Microarray

        • NGS

        • Others

      • By Workflow

        • Isolation & Purification

        • Whole Blood

        • Serum

        • Plasma

        • FFPE

        • Fresh Frozen Tissue

        • Others

      • miRNA cDNA Synthesis

      • Profiling, Localization, & Quantification

      • Functional Analysis & Others

      • Others

    • Consumables

      • By Specimen

        • Whole Blood

        • Serum

        • Plasma

        • FFPE

        • Fresh Frozen Tissue

        • Others

      • By Workflow

        • Isolation & Purification

        • miRNA cDNA Synthesis

        • Profiling, Localization, & Quantification

        • Functional Analysis

        • Others

  • Services Outlook 

    • Service Type

      • Isolation & Purification

      • miRNA cDNA Synthesis

      • Profiling, Localization, & Quantification

      • Functional Analysis

        • Real Time PCR

        • Microarray

        • NGS

        • Others

      • Others

    • By Specimen

      • Whole Blood

      • Serum

      • Plasma

      • FFPE

      • Fresh Frozen Tissue

      • Others

  •  Application Outlook

    • Cancer

    • Infectious Diseases

    • Immunological Disorder

    • Cardiovascular Disease

    • Neurological Disease

    • Others

  •  End-use Outlook

    • Biotechnology & Pharmaceutical Companies

    • Academic & Government Research Institutes

    • Other end-users

  • Regional Outlook 

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

      • France

    • Asia Pacific

      • Japan

      • China

      • India

    • Latin America

      • Brazil

    • Middle East & Africa

      • South Africa

The MicroRNA market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of MicroRNA market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global MicroRNA market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the MicroRNA market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted MicroRNA market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the MicroRNA capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of MicroRNA by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global MicroRNA market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major MicroRNA market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of MicroRNA market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the MicroRNA industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The MicroRNA market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to MicroRNA market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of MicroRNA market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new MicroRNA market. These factors have benefited the growth of the global market for MicroRNA. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for MicroRNA. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of MicroRNA are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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