Nucleic Acid Labeling Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2028

The global Nucleic Acid Labeling market size is expected to be worth around US$ 3.25 billion by 2028, according to a new report by Vision Research Reports.

The global Nucleic Acid Labeling market size was valued at US$ 1.65 billion in 2020 and is anticipated to grow at a CAGR of 8.83% during forecast period 2021 to 2028.

Growth Factors

Technological advancements with respect to nanotechnology, and are expected to help enhance the market potential in the near future. Additionally, nucleic acid labeling products are gaining significant momentum across diagnostic as well as therapeutic interventions associated with cancer disorders and genetic deformities, thereby elevating the market growth.

Technologies that enable direct detection of specific sequences of RNA or DNA serve as occasional potent alternatives to amplification protocols employed in gene expression studies. Research activities performed on these lines have also led to the development of novel label protocols such as that of incorporating probes that are specifically labeled with anti-label antibodies conjugated via alkaline phosphatase. This direct detection technique employing the use of specific labeled probes has emerged as a reliable and flexible approach for gene expression analysis, well-suited for high-throughput screening.

The continuing quest for designing labels with enhanced functional properties suitable for hybridization assays has led to the introduction of an array of potential approaches to label nucleic acids that are inclusive of genes encoding enzymes, microparticles, and a novel class of fluorophores.

Report Highlights

The reagents segment accounted for the largest share of 42.79% in 2020. This is attributed to the high costs and routine usage of the same in both chemical and enzymatic labeling protocols.  The dominance of reagents is attributed to the recurrent usage of these products in labeling protocols, followed by continuous developments in this area to further enhance the efficiency of these protocols. While chemical methods serve as a pertinent method for large-scale nucleic acid labeling, enzymatic methods have proven to be an affordable approach for small-scale probe generation applications; both methods make routine use of conventional and novel enzymes.

The kits segment is expected to as the most lucrative segment, registering a CAGR of 9.35% from 2020 to 2027. Manufacturers are focusing on designing kits that extend across varied applications, further increasing the introduction of cutting-edge nucleic acid labeling kits in the market. 

The radioactive labels segment accounted for the largest share of 65.99% in 2020. Radiolabeled nucleotides are most preferred across various applications related to nucleic acid sequences for their detection. These labeled nucleic acid sequences are largely incorporated into RNA and DNA via enzyme-based methods for analytical purposes. 

Non-radioactive nucleotide labels are presently being used extensively owing to their sensitivity, safety, relative speed, and versatility. Additionally, the most frequently employed labels include fluorescent tags. These tags are synthesized, followed by their incorporation in oligonucleotides, which has further proved useful for several therapeutic applications. Apart from the oligonucleotides, these tags can also be attached to distinct proteins, molecules, and groups that are chemically active, such as streptavidin, biotin, or fluorophores.

The enzyme-based method segment accounted for the largest share of 57.12% in 2020, which is cumulative revenue generated by PCR, 5' end labeling, 3' end labeling, and other enzyme-based methods. The dominance of the enzyme-based method over the chemical-based method is attributed to its high adoption and preference in generating small-scale probes. Enzymatic methods also present an economical approach.

However, the selection of an apt labeling method partially relies on the desired degree of labeling, followed by the predictable reactions resulting from the modifications. Enzymatic as well chemical approaches have the potential to yield nucleic acids, which can be labeled at the 3′ or 5′ end of the oligonucleotide. Additionally, these approaches are gaining command across probe integration protocols applied throughout a particular sequence.

In-situ Hybridization (ISH) accounted for the largest share of over 30.02% in 2020. Nucleic acid labeling is set to gain demand in ISH applications, with the rise in the use of ISH techniques across the diagnosis of genetic disorders, such as Cri-du-chat, 22q13 deletion syndrome, Angelman syndrome, chronic myelogenous leukemia, Velocardiofacial syndrome, Prader-Willi syndrome, Down syndrome, and acute lymphoblastic leukemia.

Nucleic acids labeled with nucleotide triphosphates (NTPs) or deoxynucleotide triphosphates (dNTPs) are preferred for in-vitro experiments making use of polymerase chain reaction (PCR). Moreover, the development of probes with end labels has gained immense demand across experiments pertaining to protein interactions, specifically gel-shift assays.

The diagnostics segment accounted for the largest share of 39.81% in 2020 and is expected to maintain its lead throughout the forecast period. The research segment is expected to witness the fastest growth from 2020 to 2027. This is attributed to the extending applications of nucleic acid labels across their purification as well visualization, further assisting in the diagnosis of chromosomal aberrations and specific sequences suitable for in-situ hybridization.

North America held the largest share of 39.49% in 2020 and is expected to dominate the market throughout the forecast period. Key factors contributing to the regional market growth include the presence of developed healthcare infrastructure, favorable reimbursement scenario, and high accessibility of novel diagnostic solutions due to the strong presence of key market players in this region.

The Asia Pacific market is expected to expand at the fastest growth rate during the forecast period. This growth is attributed to the emergence of local players and the increasing penetration of key players in the Asia Pacific region. The emerging companies are tapping on the opportunities by providing a wide array of labeling solutions in developing nations.

Key Players

  • PerkinElmer, Inc.

  • F. Hoffmann La-Roche AG

  • General Electric Healthcare Life Sciences

  • Thermo Fisher Scientific Inc.

  • Promega Corporation

  • New England Biolabs

  • Enzo Biochem, Inc.

  • Vector Laboratories Inc.

  • Merck KGaA

  • Agilent Technologies

Market Segmentation

  • Product Outlook

    • Kits

    • Reagents

    • Instruments

  • Labeling Type Outlook 

    • Radioisotope/Radioactive Labels

    • Non-radioactive Labels

  • Method Outlook

    • Enzyme-based

      • PCR

      • 5' end labeling

      • 3' end labeling

      • Others

    • Chemical-based

      • Conjugation

      • Photoreaction

  • Application Outlook 

    • Oligonucleotide Labeling

    • In-situ Hybridization

    • Southern & Northern Blotting

    • Cellular Localization

    • Others

  • Sector Outlook

    • Diagnostics

    • Research

    • Therapeutics

  • Regional Outlook 

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

      • France

    • Asia Pacific

      • Japan

      • China

      • India

    • Latin America

      • Brazil

    • Middle East Africa (MEA)

      • South Africa

The Nucleic Acid Labeling market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Nucleic Acid Labeling market for the base year 2020 and the forecast between 2021 and 2028. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Nucleic Acid Labeling market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Nucleic Acid Labeling market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Nucleic Acid Labeling market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Nucleic Acid Labeling capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Nucleic Acid Labeling by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Nucleic Acid Labeling market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2028. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Nucleic Acid Labeling market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Nucleic Acid Labeling market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Nucleic Acid Labeling industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The Nucleic Acid Labeling market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Nucleic Acid Labeling market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Nucleic Acid Labeling market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Nucleic Acid Labeling market. These factors have benefited the growth of the global market for Nucleic Acid Labeling. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Nucleic Acid Labeling. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Nucleic Acid Labeling are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2020
  • Forecast Year 2021 to 2028

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2028);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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