Protein Crystallization Market (By Type: Consumables, Reagents Kits, Instruments; By Technology; By Application; By End-user) - Global Industry Analysis, Size, Share, Growth, Trends, Revenue, Regional Outlook and Forecast 2022-2030

The global protein crystallization market size was estimated at around USD 1.2 billion in 2021 and it is projected to hit around USD 2.63 billion by 2030, growing at a CAGR of 9.1% from 2022 to 2030.

Protein Crystallization Market Size 2021 to 2030

Crystallization is the process of the formation of 3D structured molecule from a liquid substance. Protein crystallization is the process of the formation of pure and saturated protein crystals containing millions of protein molecules arranged in an orderly manner. The proteins are dissolved in the aqueous sample solution until they become supersaturated. For this purpose, the methods such as microdialysis, and diffusion are used. Crystallization of proteins is also a technique for purification. These crystallized proteins are used for X-ray crystallography.

Scope of The Report

Report Coverage Details
Market Size in 2021 USD 1.2 billion
Revenue Forecast by 2030 USD 2.63 billion 
Growth rate from 2022 to 2030 CAGR of 9.1%
Base Year 2021
Forecast Period 2022 to 2030
Segmentation Type, Technology, Application, End user, Region 
Companies Covered

Rigaku Corporation, Hampton Research Corp, HiMedia Laboratories, Bruker Corporation, Thermo Fisher Scientific, Inc., Jena Bioscience GmbH, Agilent Technologies, Charles River Laboratories, Inc., Molecular Dimensions Ltd., Formulatrix, Inc., MiTeGen LLC


Following are the steps of protein crystallization:-

  • Characterization: Proteins are purified and characterized using CD spectroscopy. This is done to study the structure, activity, and stability of protein which completes the process of crystallography.
  • Crystallization: Supersaturated protein solutions are formed with the help of salts and buffers. Large pure protein crystals are formed and subjected to X-ray crystallography.

The important applications of crystallization are:-

1. Medical chemistry via studying the structural biology (study of drug receptor interaction to improve drug efficacy),

2. Developing, scaling up, purification, and separation of therapeutic proteins,

3. Formulation and drug delivery.

The rise in infectious diseases has boosted the demand for the production and development of therapeutic products and vaccine development. Therapeutic proteins have a wide range of applications in treating cancer. The increasing prevalence of cancer disease spurs the market growth.

The increasing number of product launches and increasing efforts to find the solution for the diagnosis and treatment of chronic diseases by the biotechnology and pharmaceutical industries also has a positive impact on the market. In July 2022, Redwire Corporation announced that it would develop new manufacturing techniques for the development of small pharmaceutical protein crystals and other molecules for R&D and production. The high resolution imaging of the crystal structures provides the precise results which fuels the crystallization market. However, a lack of qualified researchers for handling crystallization protocol can hamper the market growth.

The crystallization market is segmented based on type, technology, application, end-use, and region. The type segment is further segmented into consumables, reagent kits, instruments, software, and services. The technology segment is divided into small-angle X-ray scattering, X-ray crystallography, cryo-electron microscopy, NMR spectroscopy. The application segment is divided into therapeutic protein production, drug delivery, and medical chemistry. End use segment is classified into pharmaceutical companies, biotechnology companies, and others.

Based on regional analysis the market is segmented into North America, Europe, Asia-Pacific, Latin America, the Middle East, and Africa. North America holds the major share in crystallization market. This is due to the increase in R&D investments and collaboration by the major key players in this region. Also, the increased government funding for proteomic research and the development of structure-based drugs enhances the market growth. Asia Pacific and Europe also have high investments in the R&D sector by the key players of pharmaceutical and biotechnology company which boost the crystallization technology.

Major companies operating in the protein crystallization market include Rigaku Corporation, Hampton Research Corp, HiMedia Laboratories, Bruker Corporation, Thermo Fisher Scientific, Inc., Jena Bioscience GmbH, Agilent Technologies, Charles River Laboratories, Inc., Molecular Dimensions Ltd., Formulatrix, Inc., MiTeGen LLC among others.

Market Segmentation

By Type Outlook

  • Consumables
  • Reagent Kits
  • Instruments 
    • Liquid Handling Instruments
    • Crystal Imaging Instruments
  • Software and Services

By Technology Outlook

  • X-ray Crystallography
  • NMR Spectroscopy
  • Cryo-electron Microscopy
  • Small-angle X-ray Scattering (SAXS)

By Application Outlook

  • Therapeutic protein production
  • Drug delivery
  • Medical chemistry
  • Others

By End user Outlook

  • Pharmaceutical Company
  • Biotechnology Company
  • Others

By Region Outlook

  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • Middle East And Africa

Report Detail

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