Protein Expression Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2022-2030

The global Protein Expression market size is expected to be worth around US$ 13.0 billion by 2030, according to a new report by Vision Research Reports.

The global Protein Expression market size was valued at US$ 11.2 billion in 2020 and is anticipated to grow at a CAGR of 20.4% during forecast period 2021 to 2030.

Growth Factors

 The growing demand for biologics and expansion of the biopharmaceutical industry have resulted in massive growth of the protein expression market. Rising demand for therapeutic proteins such as insulin, hormones, monoclonal antibodies,and vaccines is a major factor that propels growth of the market during forecast period. Thus, many biotechnology and pharmaceuticals companies have begun to concentrate on the development and manufacturing of advanced therapeutic proteins for the treatment of severe chronic diseases such as cancer, hemophilia, infectious diseases, anemia, and multiple sclerosis.

Increasing investment in the R&D, by biotechnology and pharmaceutical companies, is another major factor supporting the sector growth. The availability of new and advanced technologies to cater the needs of drugs & biologics product manufacturers boosts the adoption of protein expression products for research and manufacturing applications. In addition, several pharmaceutical and biotechnology manufacturers are undergoing collaborations and partnerships to achieve leadership in the sector. For instance, in December 2016, Takara Bio, Inc. signed a merger agreement with Rubicon Genomics, Inc. to strengthen its genomics business.

Report Highlights

The main expression systems used for synthesis, modification, and regulation of proteins in living organisms are prokaryotic, a mammalian cell, an insect cell, and yeast. Prokaryotic expression systems were the highest revenue-generating segment in 2020 due to its large application, high production capacity, and inexpensive production.

Manufacturers are focusing on mergers, acquisitions, and collaboration to expand their product portfolio and to strengthen their position in the industry. For instance, in January 2017, Bio-Rad Laboratories, Inc. entered into an agreement to acquire RainDance Technologies, Inc., a leading provider of ultra-sensitive genomic tools, and have strong distribution channel worldwide.

The mammalian cell expression systems segment is projected to showcase the highest growth rate during the study period. This is due to the rise in the popularity of these systems for the production of biopharmaceuticals and research applications. This system provides several advantages including the production of post-translational modified proteins and high efficiency in drug discovery and preclinical studies.

The insect cell and yeast systems segments are also expected to grow at lucrative CAGR during the forecast period, because of increasing focus on proteomics research and rising government support for research activities. The availability of advanced systems such as the BaculoDirect Baculovirus Expression System and Bac-to-Bac Baculovirus Expression System is another factor driving the growth of the segment.

The protein expression products such as reagents, expression vectors, competent cells, and instruments are widely used by research institutes, biotechnology, and pharmaceutical companies for research, development, and manufacturing of insulin, human growth hormone, therapeutic antibodies, vaccine, and other products.

In 2016, the reagents segment was the largest revenue grossing segment of the market due to the large application of these products for research and biopharmaceuticals manufacturing. The repetitive purchase of reagents for various applications including therapeutic, industrial, and research is expected to boost the market growth.

The services segment is anticipated to witness the fastest growth rate during the study period due to the escalating trend of services for custom optimization of protein expression. In addition, the service providers are equipped with advanced products and research specialists, which is expected to propel the demand for protein expression services by manufacturers and research laboratories.

The demand for vaccines and therapeutic proteins is high due to the increasing prevalence of chronic diseases such as cancer, anemia, hemophilia, infectious diseases, and multiple sclerosis. Thus, the manufacturers are using advanced products including reagents, vectors, and competent cells for the development and manufacturing of vaccines and therapeutic proteins.

Protein expression is used for various applications in research, diagnostics, and therapeutics. The therapeutic proteins such as insulin, monoclonal antibodies, growth factors, hormones, blood factors, anticoagulants, enzymes, interleukins, and interferons are widely used products for the treatment of chronic diseases.

The therapeutic application segment dominated the overall sector in terms of revenue in 2020. This is due to the large application of protein expression for the production of biologics. These products provide high accuracy, efficiency, and quality in biologics production. This segment is also projected to grow at the highest rate during the forecast period owing to the growing popularity of therapeutic proteins over other drugs.

The research applications segment is also expected to grow at lucrative CAGR during the study period owing to rising government funding for proteomics and genomics research. For instance, in June 2020, the French government announced a plan to invest around USD 760.8 million in personalized medicine and genomics program to enhance the prevention and diagnosis of chronic diseases including cancer, diabetes, and rare diseases.

The U.S., U.K., Germany, France, China, Japan, and India are projected to account for the largest application of protein expression. The presence of big biopharmaceutical and biotechnology companies, the presence of well-developed healthcare infrastructure, and the availability of advanced products in these countries are some major factors contributing to market growth.

The pharmaceutical and biotechnological companies accounted for the largest revenue share in the market due to rising demand for therapeutic proteins such as insulin, growth hormone, and vaccines. In addition, increased investment in new drug designing and development is also contributing to market growth.

The contract research organization segment is projected to showcase the highest growth rate over the study period owing to the rising outsourcing activities by biotechnology and pharmaceutical companies for research and development of new drugs and biologics.

Well-developed healthcare infrastructure in the U.S. and some European countries like UK, Germany, and France have spurred the demand for advanced therapeutic products for chronic disease treatment. In addition, rising disposable income and improving healthcare infrastructure in developing countries such as China, India, Argentina, and Brazil is expected to boost market growth.

The rising popularity of biopharmaceuticals and growing healthcare awareness in developing countries such as India, China, South Africa, and Argentina are expected to boost sector growth. The demand for vaccines and advanced biologics is increasing in these countries owing to the rising burden of chronic diseases including diabetes, cancer, and hepatitis. The focus of companies to develop and manufacture novel biologicals along with availability advanced technologies are projected to drive the application of protein expression in the healthcare industry.

North America dominated the protein expression industry with the largest revenue share, because of the presence of many large biopharmaceuticals, biotechnology, and pharmaceutical companies such as Pfizer Inc., Merck KGaA, F. Hoffmann-La Roche Ltd, and Amgen Inc. in this region.

Highly developed healthcare infrastructure and a high focus on proteomics and genomics research activities in European countries such as France, Switzerland, UK, and Germany have fueled the growth of the European market. Also, the rising demand for biologics in this region due to the high prevalence of diabetes in this region is expected to propel the growth of the market.

Asia Pacific market is expected to grow at the highest CAGR during the forecast period, owing to rising penetration of contract research organizations and developing healthcare infrastructure in Asian countries including India and China. The availability of a massive genome pool, a large number of patients, accessibility of skilled personnel, and less stringent regulation for biologics production in Asian countries have propelled the sector growth in this region.

Key Players

Agilent Technologies, Inc., Thermo Fisher Scientific Inc., Bio-Rad Laboratories, Inc., Merck KGaA, Promega Corporation, New England Biolabs, Qiagen, and Takara Bio, Inc. share market with local vendors.

Market Segmentation

  • Expression Systems Outlook 

    • Prokaryotic expression systems

    • Mammalian cell systems

    • Insect cell systems

    • Yeast systems

    • Other systems

  • Product Outlook

    • Reagents

    • Competent cells

    • Expression vectors

    • Services

    • Instruments

  • Application Outlook 

    • Therapeutic

    • Industrial

    • Research

  • End-use Outlook

    • Pharmaceutical and biotechnological companies

    • Academic research

    • Contract research organizations

    • Others

  • Regional Outlook

    • North America

      • The U.S.

      • Canada

    • Europe

      • Germany

      • UK

    • Asia Pacific

      • Japan

      • China

      • India

    • Latin America

      • Brazil

      • Mexico

    • MEA

      • South Africa

The Protein Expression market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Protein Expression market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Protein Expression market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Protein Expression market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Protein Expression market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Protein Expression capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Protein Expression by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Protein Expression market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Protein Expression market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Protein Expression market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Protein Expression industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The Protein Expression market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Protein Expression market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Protein Expression market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Protein Expression market. These factors have benefited the growth of the global market for Protein Expression. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Protein Expression. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Protein Expression are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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