Single-Cell Genome Sequencing Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2030

Published Date : Apr 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global Single-Cell Genome Sequencing market size is expected to be worth around US$ 12.49 billion by 2030, according to a new report by Vision Research Reports.

The global Single-Cell Genome Sequencing market size was valued at US$ 830.53 million in 2020 and is anticipated to grow at a CAGR of 24.6% during forecast period 2021 to 2030.

Growth Factors

Advancements in the field of single-cell analysis are anticipated to boost the growth of the market in the coming years.

Moreover, active participation and contribution of market players toward product upgradation are playing an important role in the growth of the market. Increasing number of collaborations and strategic alliances between companies are fostering the development of a collaborative portfolio in the system.

Moreover, emergence of next-generation sequencing (NGS) has helped the market gain tremendous traction over the past few years. Earlier, single-cell genome sequencing market was dominated by PCR and microarray technologies. However, qPCR and NGS are increasingly emerging as the preferred technologies.

Furthermore, rising number of single-cell genome sequencing centers & associated facilities worldwide is fostering growth prospects. The main objective of such entities is to develop novel single-cell genome sequencing-based applications and methods. These centers are also playing a major role in introducing advanced tools & instruments for scientific communities of various regions. This, in turn, is helping augmenting growth opportunities for the market.

In addition, public-private collaborations among governments, companies, and research institutions in the space are expected to promote more research initiatives. Various funding grants by NIH and private players such as Mission Bio are escalating the growth of the market.

Report Highlights

Instruments accounted for the largest revenue share in 2016. Development and implementation of technologically advanced instruments and solutions are projected to drive the growth of the segment in the near future. For instance, C1 system allows preparation of templates for DNA sequencing, mRNA sequencing, miRNA expression, or epigenetics. This C1 system allows simultaneous isolation, lysis, staining, neutralization, and whole genome amplification of up to 96 cells. It offers unbiased amplification and allows genomes to be represented properly with higher uniformity & reproducibility. The segment will maintain its dominance until 2025, expanding at the highest CAGR during the forecast period.

Technology Insights

NGS is likely to be the fastest growing technology segment in the market. The growth of the segment can be attributed to extensive R&D activities and a wide range of applications in cancer-related investigations. Genome sequencing involves gene isolation, whole-genome amplification & construction, and finally sequencing of DNA. Researchers have developed combinatorial indexed sequencing tools that find application in clinics, guiding targeted therapies, and noninvasive monitoring.

In addition, microarray enables quantification of thousands of genes by hybridization of biological samples to an array, which carries thousands of synthetic oligonucleotides probes. However, after the arrival of the NGS technology, use of microarray systems has decreased. Several companies such as Illumina, Inc. are engaged in providing advanced microarray systems for SCG applications.

Moreover, multiple displacement amplification (MDA) is the most widely used process for whole-genome amplification prior to SCGS. Various studies have demonstrated the proof-of-principle of eWGA with MDA. This easy-to-operate method enables researchers to simultaneously detect copy number variations (CNVs) and single nucleotide polymorphism (SNPs) in an individual human cell and significantly improves amplification accuracy and uniformity.

Recent developments have created new opportunities to quantify mutation rates, identify rare cell types, characterization of intra-tumor cellular heterogeneity, and guide diagnosis & treatment. SCG analysis is also used for reconstruction of tissues in multicellular organisms.

Fluidigm is one of the leading players that provides SCGS-based techniques and technologies. Fluidigm developed complex microfluidics systems and used it for single-cell oriented studies. In addition, entities such as Illumina, Inc. and 10x Genomics are actively engaged in developing advanced genome analysis platforms.

Furthermore, development of microfluidic devices is leading to integration of steps involved in sequencing sample preparation and library generation for up to 96 samples. These systems can also reduce the DNA input requirements by 100 folds while improving data handling. Use of completely integrated sample preparation systems, based on lab-on-chip methods, overcome technical barriers to enable broader utilization of genomics across translational and basic investigational applications.

Cancer commanded the dominant share in the single cell genome sequencing market in 2016. Increasing incidence of prostate, colorectal, and breast cancer is poised to create lucrative growth opportunities. According to WHO, around 8.8 million deaths were reported in 2015 due to different types of cancers.

In addition, initiatives by various organizations such as the American Cancer Society & Breast Cancer Organization are also anticipated to boost growth. For instance, the American Cancer Society has approved funding of USD 39 million for cancer research and training. Such funding is expected to facilitate technological advancements in cancer research and diagnosis.

Circulating cells represented the leading share in the market in 2016. Widening clinical applications of circulating tumor cells (CTCs) as a biomarker for cancer detection is supplementing the growth of the segment. Furthermore, various investigations proved that a cell-free DNA exhibits a good representation of tumor genome in lung cancer and late-stage gastric cancer. When cell-free DNA is sequenced with tumor origin, it identifies biomarkers associated with the tumor, which helps determine molecular pathology.

they are also used for genomic profiling of sequence mutations or copy in disseminated tumor cells and CTCs. Such studies in the area are estimated to stimulate the growth of the market over the forecast period. It also aids in accurate diagnosis of the condition.

Academic & research labs are projected to be the highest revenue contributor throughout the forecast period. The dominance of the segment can be attributed to rising genomic centers and ongoing investigations in this field. Several genomic centers are engaged in exploring genome, transcriptome, and epigenome of single cell to understand disease pathology and its progression. Organization also provide high-throughput isolation and sequence library preparation services.

Government and various private organizations provide funding for advancements in this field. In addition, the presence of a large number of research facilities, especially in developed countries, is likely to augment the market over the forecast period. Usage of sequencing kits to understand the morphology and functioning of several roles of genes in various chronic conditions are anticipated to drive the demand for single cell genome sequencing in the coming years.

North America was at the forefront of the market in 2016, with the U.S. being the key revenue contributor. Some factors responsible for the dominance of this region are mounting cases of cancer, immunological disorders, and neuropsychiatric diseases coupled with technological advancements brought about by entities operating in the region.

Moreover, increasing investigations in genomics are poised to trigger the growth of the market over the forecast period. For instance, research on microfluidic droplet barcoding at ultra-high-throughput analyzed distributions of phage sequences, antibiotic resistance genes, and virulence factors in microbial communities from an environmental sample. Researchers at the University of California conducted this study.

Key Players

Bio-Rad Laboratories; 10x Genomics; Novogene; Fluidigm; BGI; Illumina, Inc.; Oxford Nanopore Technologies; Pacific Biosciences; Thermo Fisher Scientific, Inc.; QIAGEN; and F Hoffmann-La Roche Ltd.

Market Segmentation

  • Product Outlook

    • Instruments

    • Reagents

  • Technology Outlook

    • NGS

    • PCR

    • qPCR

    • Microarray

    • MDA

  • Workflow Outlook

    • Isolation

    • Sample preparation

    • Genomic analysis

  • Disease Area Outlook

    • Cancer

    • Immunology

    • Prenatal diagnosis

    • Neurobiology

    • Microbiology

    • Others

  • Application Outlook

    • CTCs

    • Differentiation/ reprogramming

    • Genomic variation

    • Subpopulation characterization

    • Others

  • End-use Outlook 

    • Academic & Research Laboratories

    • Biotechnology & biopharmaceutical companies

    • Clinics

    • Others

  • Regional Outlook

    • North America

      • The U.S.

      • Canada

    • Europe

      • Germany

      • The U.K.

    • Asia Pacific

      • Japan

      • China

    • Latin America

      • Brazil

    • Middle East and Africa (MEA)

      • South Africa

 

The Single-Cell Genome Sequencing market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Single-Cell Genome Sequencing market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Single-Cell Genome Sequencing market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Single-Cell Genome Sequencing market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Single-Cell Genome Sequencing market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Single-Cell Genome Sequencing capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Single-Cell Genome Sequencing by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Single-Cell Genome Sequencing market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Single-Cell Genome Sequencing market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Single-Cell Genome Sequencing market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Single-Cell Genome Sequencing industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The Single-Cell Genome Sequencing market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Single-Cell Genome Sequencing market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Single-Cell Genome Sequencing market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Single-Cell Genome Sequencing market. These factors have benefited the growth of the global market for Single-Cell Genome Sequencing. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Single-Cell Genome Sequencing. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Single-Cell Genome Sequencing are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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