T-cell Therapy Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2022-2030

Published Date : Feb 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global T-cell Therapy market size is expected to be worth around US$ 20.8 billion by 2030 from valued at US$ 4.9 billion in 2021 and is anticipated to grow at a CAGR of 20.4% during forecast period 2022 to 2030.

Report Takeaway

  • North America accounted for the largest revenue share of around 41% in 2021
  • Asia-Pacific is projected to witness the fastest CAGR with emerging markets such as China at the forefront
  • In 2021, the hematologic malignancies indication segment accounted for a 51% revenue share.
  • In 2021, CAR T-cell therapy type segment accounted for the largest revenue share of 83% in 2021
  • By Modality, the research segment dominated accounted 76% of revenue share in 2021 

Growth Factors

The milestone approvals of Kymriah and Yescarta along with the recent approval of Tecartus have bolstered the exponential revenue growth in the market.

The commercial launch of these innovative therapies across various regions has spurred the investment flow in this arena thereby driving the market. Cancer indications are the major investment targets for the key operating players. However, space is constantly expanding to include other indications such as viral infections, creating lucrative opportunities for the operating players.

Engineered T-cell marketspace is characterized by an in-depth network of several entities marked by financially, academically, and licensing agreements. Collaborations between research bodies and manufacturers to assess the efficacy and safety of therapies are anticipated to put forth the advancements in the space, thereby expected to result in the anticipated success of the market.

By far, the wider application of CAR-T therapies has been hampered by the considerable lack of efficiency to treat solid tumors and linked toxicity concerns due to the strong immunosuppressive tumor microenvironment. Thus, operating players are engaged in implementing new approaches to overcome these challenges and expand the application in solid.

Modality Insights

The research segment dominated the market for T-cell therapy and accounted for more than 75.0% of revenue share in 2020 owing to the high number of products in the clinical development phase. A substantial number of research institutes such as Mayo Clinic are actively engaged in conducting CAR-T therapy programs thus supporting the method as a preferable method of cancer management.

Several operating entities are collaborating with research communities across the globe, resulting in the shift in focus on accelerating the development of CAR-T therapies to expand the therapeutic application landscape. For instance, in October 2020 Immuneel Therapeutics collaborated with Institut d’Investigacions Biomèdiques August Pi i Sunyer and Hospital Clínic de Barcelona for the development and commercialization of CAR-T therapy in India.

On the other hand, regulatory bodies are making focused efforts to propel the commercial use of these therapies in clinical and hospital settings. In August 2020, the Centers for Medicare and Medicaid Services (CMS) policies for reimbursement and coverage of CAR-T cell therapy. This policy increased the payment received to 65% of the total cost. This would spur commercial revenue growth.

Therapy Type Insights

In 2020, CAR T-cell therapy segment dominated the market for T-cell therapy and accounted for the largest revenue share of 82.0% in 2020. This is owing to the exponential rise in the number of clinical trials for CAR-T therapies and the increasing involvement of key players in this arena. A substantial number of new entrants and academic institutions are conducting clinical trials for CAR-T therapeutic products for different as well as same indications, consequently supporting the dominance of the segment.

Advancements in CAR-T therapy manufacturing enhanced the uptake of these therapies in the treatment of various cancers. The emergence of new approaches such as second-generation, next-generation CAR-T immunotherapy may overcome the challenges like resistance, side effects thus, leading to growth in organic revenue generation.

Besides this, T-cell receptor-based therapies pegged the second position in the global space owing to their potential in the treatment of solid tumors. This segment is gaining significant attention for the treatment of melanoma. Adaptimmune is one of the companies that focuses on TCR therapy for melanoma in collaboration with GlaxoSmithKline.

Indication Insights

In 2020, the hematologic malignancies segment dominated the market for T-cell therapy and accounted for a 49.0% revenue share. The CAR-T-cell therapies have been predominantly used to treat hematological malignancies including lymphoma, leukemia, and myeloma. Given the high number of market entities entering the market and high fixed costs of autologous cell manufacturing, the segment is expected to witness high market competition in the near future.

The CAR-T cell therapies have made remarkable advancements in hematological malignancies, resulting in segment saturation in terms of number of market players operating in the segment. As a result, several competitors are now shifting their focus on the development of treatments for solid tumors to capitalize on the untapped avenues of the market. The development of affordable and effective therapy for solid tumors presents lucrative opportunities for the operating key stakeholders.

Viral infections such as COVID-19 and HIV have expanded the landscape of T-cell therapies. Several CARs targeting viral infections have made tremendous progress in recent years. Anti-HIV CAR-T cell therapy has reached clinical trial whereas others such as HCV, HBV are in pre-clinical development. This is anticipated to spur the revenue flow in non-cancer indications.

Regional Insights

North America dominated the T-cell therapy market and accounted for the largest revenue share of around 40.0% in 2020. The presence of strong research, as well as a commercial base coupled with a high number of clinical trials being conducted for T-cell therapies in the U.S., has majorly contributed to the dominance of the market in the region.

Furthermore, the increasing number of regulatory approvals in the U.S. and Canada along with the changing reimbursement scenario in the region has also accelerated the uptake of these therapies leading to significant market growth. In addition, the presence of a substantial number of medical centers offering CAR-T cell therapies also supports the regional market growth.

In recent years, China has emerged as a potential market for CAR-T therapies with the highest number of registered clinical trials pertaining to these therapies. Focused efforts on government investment and reforms in the country have resulted in significant growth consequently exhibiting the fastest CAGR in the region.

Key Players

  • Novartis AG

  • Merck KGaA

  • Gilead Sciences Inc.

  • TCR2 Therapeutics Inc

  • Bluebird Bio Inc.

  • Sorrento Therapeutics

  • Fate Therapeutics

  • Pfizer Inc.

  • Amgen

  • Celgene Corporation

Market Segmentation

  • Modality Outlook 

    • Research

    • Commercialized

  • Therapy Type Outlook 

    • CAR T-cell Therapy

    • T Cell Receptor (TCR)-based

    • Tumor Infiltrating Lymphocytes (TIL)-based

  • Indication Outlook 

    • Hematologic Malignancies

      • Lymphoma

      • Leukemia

      • Myeloma

    • Solid Tumors

      • Melanoma

      • Brain & Central Nervous System

      • Liver Cancer

      • Others

    • Others

  • Regional Outlook 

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • U.K.

    • Asia Pacific

      • Japan

      • China

    • Latin America

      • Brazil

    • Middle East and Africa (MEA)

      • South Africa

The T-cell Therapy market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of T-cell Therapy market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global T-cell Therapy market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the T-cell Therapy market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted T-cell Therapy market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the T-cell Therapy capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of T-cell Therapy by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global T-cell Therapy market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major T-cell Therapy market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of T-cell Therapy market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the T-cell Therapy industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The T-cell Therapy market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to T-cell Therapy market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of T-cell Therapy market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new T-cell Therapy market. These factors have benefited the growth of the global market for T-cell Therapy. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for T-cell Therapy. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of T-cell Therapy are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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