Targeted DNA RNA Sequencing Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2030

Published Date : Mar 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global Targeted DNA RNA Sequencing market size was valued at US$ 14.15  billion in 2020 and is expected to be worth around US$ 17.2 billion by 2030.

Growth Factors

Numerous studies are being carried out to demonstrate the remarkable reduction in cost per sample by sequencing the relevant regions of the genome, which are informative. As a result, targeted methods have begun to supplant other WGS/WES methods in biomedical research. Furthermore, technological advancements are being made in enrichment protocols to standardize and simplify the seq-processes, which drives the market. These advancements have enabled faster analysis as they reduce presequencing time.

The anticipated progress of this market can also be attributed to the introduction of digital Next-Generation Sequencing (NGS) technology. This technology allows better target quantification by enabling number counting of only unique molecular identifiers, that are attached to the DNA molecules prior to amplification, in the reads, instead of counting total reads. Moreover, gene testing has increased the pool of data, which has enabled researchers, physicians, and patients to further understand genetic susceptibility to certain diseases. 

The utilization of this data pool in clinical practices is expected to positively influence the adoption rate in this market. Although a surge in the adoption of this technology has been observed, it is still not widely used in certain developing and emerging economies. Lack of trained personnel and high installation/ maintenance costs are expected to limit the growth of this market during the forecast period.

Report Highlights

NGS-based methods dominated the market in 2020 and are anticipated to maintain their dominance during the forecast period. Its large share can be attributed to the presence of a substantial number of high-throughput sequencers for studying mutations in a specific region of the genome. Targeted NGS simultaneously screens several hundred to thousands of genes. Furthermore, the plummeting cost of seq-process has made NGS technology more accessible to scientists. 

The significant success of NGS technology is evident by the continuous increase in the number of genome projects that are based on next-generation targeted approaches. In addition, players continue to make investments to develop next-generation targeted methods as they understand their significance. Enrichment seq., exome seq., and amplicon seq. are recognized as major NGS methods. Exome seq. is the most widely used method and its adoption is increasing at a faster rate than any other method.

Sanger sequencing is estimated to have less penetration in 2020 due to the advent of improved second-generation sequencers. The adoption rate of this technology is observed to be relatively low due to its accompanying pitfalls, such as low sensitivity & scalability. However, the Sanger method is simpler than the second-generation sequencing methods, where workflow is concerned. Therefore, this segment is expected to witness considerable growth in the coming years.

The entire sequencing process is broken down into pre-sequencing, sequencing, and data analysis. The sequencing process held a major share in 2020. The major factor responsible for this large share is the gradual evolution of modern sequencers for efficient sequencing of a large number of samples, which is certainly due to the increasing complexity of genome explorations. Moreover, firms have begun to develop third-generation sequencers, which in turn is expected to aid in revenue generation for this segment. 

Since the expansion of modern sequencers has a direct impact on the expansion of data output from each experiment, the growth of both segments-sequencing and data analysis-complements each other. Ongoing developments in the fields of molecular biology & gene engineering and parallelization of seq-reaction have resulted in a massive increase in the number of produced sequence reads per run. This, in turn, has increased the need for the development of data analysis solutions for handling and interpreting surplus amount of data. These factors are expected to drive the data analysis segment.

Innovation in sample preparation protocols to optimize the seq-process is expected to boost the progress of presequencing process. Furthermore, with the introduction of several novel technologies in genomic studies, a wide range of samples is incorporated into research, which has led to the development of sample preparation solutions. Presence of high-quality control measures and improved extraction & purification techniques have enabled the sequencing of a wide variety of samples, which has enhanced the progress of this segment.

Targeted approach has proven to be an efficient method for accelerating translational biomedical research. This factor is responsible for the large share held by this segment. Targeted methods have enabled the study of the complex interplay between genes involved in the development of diseases, without the risk of wastage and expending high cost. Hence, this technology is recognized as a cost-effective strategy for the detection of multiple genetic alterations from minimal DNA sample. 

Drug discovery is anticipated to significantly benefit in the coming years from the advent of this technology. Factors that are responsible for spurring the adoption of the targeted approach in this segment are the creation of diverse datasets for drug discovery, growing emphasis on the discovery of potential drug targets, and translation of genomic knowledge into the rational drug development process. 

This technology allows the mapping of regions that contain informative Single Nucleotide Polymorphism (SNPs) in plants and animals. These SNPs are associated with phenotypic differences, which has thereby revolutionized the plant and animal breeding scenario. Moreover, several studies are being conducted to illustrate the targeted approach in plant-based applications for enhancing the yield and reproducibility, consequently driving the growth of plant & animal science.

On the basis of input type, the targeted DNA RNA sequencing market is bifurcated into DNA and RNA-seq. Continuous cost reduction per raw mega-base has greatly impacted the adoption of this technology, and, in turn, resulted in the large share of this segment. Moreover, the presence of a wide range of products to facilitate DNA-seq is expected to help maintain the dominance of this segment. 

RNA-seq is expected to witness significant growth in the coming years owing to the growing use of amplicon RNA-seq technology for various disease detection procedures. Growing need for transcriptome study to evaluate disease states and cellular responses to therapeutics is expected to impel the market growth in the near future.

Various end-use segments in this market are academic research, hospitals & clinics, pharma & biotech entities, and other users. These methods are highly utilized in universities and academic entities for accelerating ongoing research projects. This can be attributed to the large share of academic research segment. Moreover, scholarships offered for NGS-based PhD projects are anticipated to positively influence the progress of this segment. 

Hospitals & clinics are expected to emerge as the fastest-growing segment as the technology generates immense opportunities for healthcare entities to improve patient outcomes. Utilizing sequencing methods, such as targeted methods, in healthcare is most likely to help doctors in making effective treatment decisions by analyzing bacterial and viral DNA from patient specimens.

Presence of a large number of genome centers with installed sequencers can be attributed to the large share of the North American region. Presence of effective regulatory bodies to review the sequencing-based genetic tests and new approval of related technologies have also added to the regional growth. Furthermore, grants from NIH to support targeted sequencing study in the country has expanded the market in this region.

Asian countries such as Japan and China are expected to emerge as a lucrative revenue source in the coming years. This is mainly due to the low prices of NGS-based tests in China compared to the tests in the U.S. Moreover, clinical laboratories in this region are continuously making efforts to meet the standard guidelines established by regulatory agencies for accreditation of NGS platforms.

Key Players

Illumina, Inc.; F. Hoffmann-La Roche Ltd; Agilent Technologies; GATC Biotech Ag; Oxford Nanopore Technologies; Thermo Fisher Scientific, Inc.; DNASTAR Inc.; QIAGEN; BGI; Perkin Elmer, Inc.; Pacific Biosciences of California, Inc.; Bio-Rad Laboratories, Inc.; Integrated DNA Technologies, Inc.; RainDance Technologies, Inc.; PierianDx; Genomatix GmbH; and Macrogen, Inc. 

Market Segmentation

  • Technology Outlook

    • NGS

      • By Methods

        • Exome Sequencing

        • Enrichment Sequencing

        • Amplicon Sequencing

        • Others

      • By Applications

        • Cancer Gene Sequencing

        • Inherited Disease Screening

        • Drug Development

        • Forensic Genomics

        • 16S ribosomal RNA (rRNA) sequencing

    • Others

  • Workflow Outlook

    • Presequencing

    • Sequencing

    • Data Analysis

  • Application Outlook

    • Human Biomedical Research

    • Plant & Animal Sciences

    • Drug Discovery

    • Others

  • Type Outlook 

    • DNA-based Targeted Sequencing

    • RNA-based Targeted Sequencing

  • End-use Outlook

    • Academic Research

    • Hospitals & Clinics

    • Pharma & Biotech Entities

    • Other Users

  • Regional Outlook

    • North America

      • The U.S.

      • Canada

    • Europe

      • Germany

      • The U.K.

    • Asia Pacific

      • China

      • Japan

    • Latin America

      • Brazil

    • The Middle East & Africa

      • South Africa

The Targeted DNA RNA Sequencing market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Targeted DNA RNA Sequencing market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Targeted DNA RNA Sequencing market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Targeted DNA RNA Sequencing market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Targeted DNA RNA Sequencing market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Targeted DNA RNA Sequencing capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Targeted DNA RNA Sequencing by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Targeted DNA RNA Sequencing market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2030. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Targeted DNA RNA Sequencing market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Targeted DNA RNA Sequencing market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Targeted DNA RNA Sequencing industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The Targeted DNA RNA Sequencing market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Targeted DNA RNA Sequencing market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Targeted DNA RNA Sequencing market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Targeted DNA RNA Sequencing market. These factors have benefited the growth of the global market for Targeted DNA RNA Sequencing. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Targeted DNA RNA Sequencing. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Targeted DNA RNA Sequencing are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2021
  • Forecast Year 2021 to 2030

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2030);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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