Upstream Bioprocessing Market Size, Share, Trends, Growth, Production, Consumption, Revenue, Company Analysis and Forecast 2021-2028

Published Date : Jan 2021 | No. of Pages : 250 Pages | Category : Healthcare

The global Upstream Bioprocessing market size is expected to be worth around US$ 12.79billion by 2028, according to a new report by Vision Research Reports.

The global Upstream Bioprocessing market size was valued at US$ 4.80 billion in 2020 and is anticipated to grow at a CAGR of 13.01% during forecast period 2021 to 2028.

Growth Factors

Commercial success and wide acceptance of biopharmaceuticals have provided lucrative growth avenues to several in house as well as contract manufacturing biopharmaceutical companies. Furthermore, a confluence of factors, such as high demand for biosimilars and biologics, launch of improved cost-effective technologies, and growing acceptance of single-use systems have driven the revenue performance of the market.

Start-ups and new market entrants often face budget constraints while establishing new biomanufacturing plants. Thus, these entities expand their biotherapeutics portfolio by outsourcing the production process to contract services, thereby aiding in revenue growth for upstream bioprocessing services.

Continuous upstream bioprocessing has greatly benefited the bioprocessing industry. Rising implementation of methods, such as acoustic wave technology and continuous centrifugation, for clarification of bioreactor cultures tends to minimize the clarification burden. This, in turn, increases the cell-culture densities, consequently resulting in efficient upstream processes.

Ongoing advancements in cell line productivity with respect to protein expression and clone screening are expected to result in the fastest CAGR of cell culture products over the forecast period. Cell culture is considered as the most challenging and crucial step in upstream bioprocessing, and thus demands more attention with respect to technological intricacies, resulting in the largest share in the upstream bioprocessing market.

Report Highlights

Availability of a wide range of bioreactors/fermenters along with the high usage of bioreactors in large as well small-scale bioproduction marks the larger revenue share of the bioreactors. Moreover, the development of automated bioreactors for safe, cost-effective, and regulatory-compliant manufacturing of cell-based products for clinical applications has driven the segment growth.

Rising demand for high titer producing cell cultures can be attributed to the lucrative growth rate of products. High adoption of recombinant Chinese Hamster Ovary (CHO) cell line as a cost-effective option provided by the established companies fuels the segment growth. On the other hand, startup biotech companies outsource the entire CHO cell-based production process for more effective biomanufacturing in terms of time and yield.

The use of patented cell lines offers a high success rate in the cell cultivation process, because the use of patented cell lines have a proven track record concerning minimal regulatory risk and efficient commercial production. Aforementioned advantages positively impact the long-term value propositions for the companies operating in the upstream bioprocessing market.

Cell culture step is expected to maintain its dominance in terms of revenue share throughout the forecast period, due to the ongoing technological advancements in cell culture systems, such as, development of micro-bioreactors to facilitate small scale bioproduction.

The developments in biological data analysis and data management fields provide critical quality attributes related to cell cultivation. Constant improvements in the high throughput analytics and development of multi-bioreactor systems have driven the revenue in this segment.

Cell separation workflow accounted for the lowest penetration with respect to revenue share is expected to grow at a significant pace in the forthcoming years. Factors that can be attributed to the projected growth include implementation of flocculants to enhance the throughput in centrifugation and the advent of single-use tubular bowl centrifuges.

Multi-use products accounted for the largest share of the market for upstream bioprocessing in 2020 due to the high usage of conventional stainless-steel bioreactors for commercial biomanufacturing. Moreover, these systems impose lower environmental impact as compared to single-use systems and are associated with minimal leakage risk during the cell culture.

On the other hand, the cost-saving advantage of the single-use products is anticipated to drive the adoption of these systems with a notable growth rate. Disposable systems abolish the need for sterilization or cleaning steps, which in turn, reduces the additional expenses incurred during sterilization, process validation, assembly, and maintenance processes, which is mandatory in multi-use assemblies.

In-house segment captured the largest revenue share due to the presence of a substantial number of well-established firms that prefer in-house manufacturing. These firms consider outsourcing as a risk associated with the loss of strategic control over the process and limited management oversight. Moreover, such manufacturers have cross-functional teams for conducting advanced production techniques during biopharmaceutical production.

North America accounted for the largest upstream bioprocessing market share in 2020. Initiatives undertaken by U.S.-based public and private entities to provide higher profit margins by the virtue of the expansion of resources in the country has contributed to the largest revenue share of this region.

Key Players

  • Thermo Fisher Scientific, Inc

  • GE Healthcare

  • Merck KGaA

  • Corning, Inc.

  • Sartorius AG

  • Eppendorf AG

  • Applikon Biotechnology

  • Lonza

  • PBS Biotech, Inc.

  • CellGenix GmbH

  • Boehringer Ingelheim

  • Samsung BioLogics

  • Patheon

  • CMC Biologics

  • Danaher Corporation

Market Segmentation

  • Product Outlook 

    • Bioreactors/Fermenters

    • Cell Culture Products

    • Filters

    • Bioreactors Accessories

    • Bags & Containers

    • Others

  • Workflow Outlook

    • Media Preparation

    • Cell Culture

    • Cell Separation

  • Use Type Outlook 

    • Multi-use

    • Single-use

  • Mode Outlook 

    • In-house

    • Outsourced

  • Regional Outlook

    • North America

      • U.S.

      • Canada

    • Europe

      • Germany

      • France

    • Asia Pacific

      • China

      • India

    • Latin America

      • Brazil

    • Middle East and Africa (MEA)

      • South Africa

The Upstream Bioprocessing market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

The report provides size (in terms of volume and value) of Upstream Bioprocessing market for the base year 2020 and the forecast between 2021 and 2028. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Upstream Bioprocessing market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Upstream Bioprocessing market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Upstream Bioprocessing market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.

In terms of production side, this report researches the Upstream Bioprocessing capacity, production, value, ex-factory price, growth rate, market share for major manufacturers, regions (or countries) and type.

In terms of consumption side, this report focuses on the consumption of Upstream Bioprocessing by regions (countries) and application.

Buyers of the report will have access to verified market figures, including global market size in terms of revenue and volume. As part of production analysis, the authors of the report have provided reliable estimations and calculations for global revenue and volume by Type segment of the global Upstream Bioprocessing market. These figures have been provided in terms of both revenue and volume for the period 2017 to 2028. Additionally, the report provides accurate figures for production by region in terms of revenue as well as volume for the same period. The report also includes production capacity statistics for the same period.

With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major Upstream Bioprocessing market companies.

Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of Upstream Bioprocessing market upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of market and consumption, major regions and Consumption, major Chinese producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.

The research in this report also includes product parameters, production process, cost structure, and data information classified by region, technology and application. Finally, the paper model new project SWOT analysis and investment feasibility study of the case model.

Overall, this is an in-depth research report specifically for the Upstream Bioprocessing industry. The research center uses an objective and fair way to conduct an in-depth analysis of the development trend of the industry, providing support and evidence for customer competition analysis, development planning, and investment decision-making. In the course of operation, the project has received support and assistance from technicians and marketing personnel in various links of the industry chain.

The Upstream Bioprocessing market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to Upstream Bioprocessing market.

Prominent players in the market are predicted to face tough competition from the new entrants. However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market. For a detailed analysis of key companies, their strengths, weaknesses, threats, and opportunities are measured in the report by using industry-standard tools such as the SWOT analysis. Regional coverage of key companies is covered in the report to measure their dominance. Key manufacturers of Upstream Bioprocessing market are focusing on introducing new products to meet the needs of the patrons. The feasibility of new products is also measured by using industry-standard tools.

Key companies are increasing their investments in research and development activities for the discovery of new products. There has also been a rise in the government funding for the introduction of new Upstream Bioprocessing market. These factors have benefited the growth of the global market for Upstream Bioprocessing. Going forward, key companies are predicted to benefit from the new product launches and the adoption of technological advancements. Technical advancements have benefited many industries and the global industry is not an exception.

New product launches and the expansion of already existing business are predicted to benefit the key players in maintaining their dominance in the global market for Upstream Bioprocessing. The global market is segmented on the basis of region, application, en-users and product type. Based on region, the market is divided into North America, Europe, Asia-Pacific, Latin America and Middle East and Africa (MEA).

In this study, the years considered to estimate the market size of Upstream Bioprocessing are as follows:

  • Historic Year: 2017-2020
  • Base Year: 2020
  • Forecast Year 2021 to 2028

Reasons to Purchase this Report:

- Market segmentation analysis including qualitative and quantitative research incorporating the impact of economic and policy aspects
- Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.
- Market value USD Million and volume Units Million data for each segment and sub-segment
- Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years
- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

Research Methodology:

In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Market Size Estimation

Top-down and bottom-up approaches are used to estimate and validate the global market size for company, regional division, product type and application (end users).

The market estimations in this report are based on the selling price (excluding any discounts provided by the manufacturer, distributor, wholesaler or traders). Market share analysis, assigned to each of the segments and regions are achieved through product utilization rate and average selling price.

Major manufacturers & their revenues, percentage splits, market shares, growth rates and breakdowns of the product markets are determined through secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or others factors are accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Vision Research Reports and presented in this report.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation. Extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report.

Secondary Sources

Secondary Sources occupies approximately 25% of data sources, such as press releases, annual reports, Non-Profit organizations, industry associations, governmental agencies and customs data, and so on. This research study includes secondary sources; directories; databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), TRADING ECONOMICS, and avention; Investing News Network; statista; Federal Reserve Economic Data; annual reports; investor presentations; and SEC filings of companies.

Primary Sources

 In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product manufacturers (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end users (product buyers), and related key executives from various key companies and organizations operating in the global market.

The study objectives of this report are:

  • To analyze and study the global market capacity, production, value, consumption, status (2017-2020) and forecast (2021-2028);
  • Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.
  • Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players
  • To define, describe and forecast the market by type, application and region.
  • To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.
  • To identify significant trends and factors driving or inhibiting the market growth.
  • To analyze the opportunities in the market for stakeholders by identifying the high growth segments.
  • To strategically analyze each submarket with respect to individual growth trend and their contribution to the market
  • To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market
  • To strategically profile the key players and comprehensively analyze their growth strategies.

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