Europe Gene Synthesis (Research Use) Market (By Method: Solid-phase Synthesis, Chip-based Synthesis; By Service; By Application; By End-use; By Research Phase) - Industry Analysis, Size, Share, Growth, Trends, Revenue, Regional Outlook and Forecast 2024-2033

The Europe gene synthesis (research use) market size was valued at USD 357.44 million in 2023 and it is predicted to surpass around USD 1,556.55 million by 2033 with a CAGR of 15.85% from 2024 to 2033.

Key Pointers

• Solid-phase synthesis segment dominated the market in 2023 with a share of 40%.
• The PCR-based enzyme synthesis method is expected to witness the fastest CAGR of 17.94% over the forecast period. 
• In the services segment, the antibody DNA synthesis segment held the largest market share of 63% in 2023.
• The viral DNA synthesis segment is expected to grow at the fastest CAGR of 18.65% during 2024-2033. 
• The gene & cell therapy development segment held a revenue share of 56% in 2023.
• The clinical segment accounted for the largest regional market share of 74% in 2023.
• The academic & government research institutions segment dominated the market with a revenue share of 44% in 2023. 
• The contract research organization end-use segment is expected to witness the fastest CAGR of 18.25% throughout the forecast period.

Europe Gene Synthesis (Research Use) Market Overview

The gene synthesis market for research use in Europe is experiencing significant growth, driven by advancements in biotechnology, increasing demand for customized genetic materials, and expanding applications in various fields such as pharmaceuticals, agriculture, and academic research. 

Europe Gene Synthesis (Research Use) Market Growth Factors 

The growth of the gene synthesis market for research use in Europe is propelled by an advancements in biotechnology have enabled the development of sophisticated gene synthesis techniques, making it easier and more cost-effective for researchers to obtain custom DNA sequences. Secondly, increasing investments in genomics research across Europe are driving the demand for gene synthesis services, particularly in areas such as drug discovery, personalized medicine, and agricultural biotechnology. Additionally, collaborations between academic institutions, biotech companies, and government organizations are fostering innovation and driving the adoption of gene synthesis technologies. Moreover, the expanding applications of synthetic genes in fields such as molecular biology, synthetic biology, and biomedicine are fueling market growth by creating new opportunities for research and product development. 

Report Scope of the Europe Gene Synthesis (Research Use) Market

Europe Gene Synthesis (Research Use) Market Trends:

• Rising Demand for Customized Genetic Materials: The European gene synthesis market is witnessing a surge in demand for custom DNA sequences, driven by the need for tailored genetic materials in various research applications, including drug discovery, functional genomics, and synthetic biology.
• Advancements in Gene Editing Technologies: The emergence of advanced gene editing technologies, such as CRISPR-Cas9, is reshaping the landscape of gene synthesis in Europe. These technologies offer precise and efficient methods for modifying DNA sequences, expanding the possibilities for genetic engineering and therapeutic development.
• Growing Adoption of High-Throughput Platforms: High-throughput gene synthesis platforms are gaining traction in Europe, enabling researchers to rapidly synthesize large numbers of DNA sequences in parallel. This trend is driven by the need for scalable and cost-effective solutions to meet the increasing demand for synthetic genes across diverse research domains.
• Integration of Artificial Intelligence (AI) and Machine Learning: The integration of AI and machine learning algorithms into gene synthesis workflows is enhancing the speed, accuracy, and efficiency of DNA sequence design and optimization. European companies are leveraging AI-driven approaches to streamline the gene synthesis process and accelerate research and development efforts.
• Expansion of Applications in Precision Medicine: Gene synthesis is playing a crucial role in advancing precision medicine initiatives in Europe, enabling the development of personalized therapies and diagnostic tools tailored to individual patient profiles. This trend is driving collaboration between research institutions, healthcare providers, and biotech companies to harness the potential of synthetic biology for improving patient outcomes.

Method Insights

Based on method, the market is segmented into solid-phase, chip-based, and PCR-based enzyme synthesis. Solid-phase synthesis segment dominated the market in 2023 with a share of 40% due to the presence and widespread use of this technique, along with the increasing automation in solid-phase technology, which enhanced the efficiency of DNA synthesis. A rise in the adoption of solid-phase synthesis for biophysical studies also favors segment demand.

The PCR-based enzyme synthesis method is expected to witness the fastest CAGR of 17.94% over the forecast period. The growth of the segment can be attributed to the restraints of the chemical synthesis process, such as producing desired quality DNA for only up to a limited length and the environmental impact of the harsh chemicals used.

Services Insights

In the services segment, the antibody DNA synthesis segment held the largest market share of 63% in 2023, owing to an increase in the adoption of gene synthesis in the production of antibodies used for research and the availability of cutting-edge recombinant technology. Furthermore, the increased importance of personalized antibodies and related research for cancer or genetic disorders drives the segment.

The viral DNA synthesis segment is expected to grow at the fastest CAGR of 18.65% during 2024-2033. Gene synthesis enables the construction of viral DNA in the laboratory without needing an existent virus sample. Moreover, the synthesis of viral genomes also assists in recognizing the gene functions and pathogenicity of the organism, allowing for the development of better treatment or disorder prevention options. These applications of viral DNA synthesis services are anticipated to drive the segment.

Application Insights

Based on application, the gene synthesis market is segmented into gene & cell therapy development, vaccine development, and others. The gene & cell therapy development segment held a revenue share of 56% in 2023, and it is anticipated to showcase the fastest CAGR over the forecast period. The dominance and growth of the segment can be attributed to several factors, including increasing gene & cell therapy approvals and the growing use of gene synthesis methods for cloning synthetic therapeutic genes in viral vectors. Moreover, the growing adoption of gene & cell therapies and increasing government support are anticipated to drive the segment in the coming years.

Research Phase Insights

Based on research phase, the Europe gene synthesis (research use) market is segmented into preclinical and clinical. The clinical segment accounted for the largest regional market share of 74% in 2023. The segment is also projected to display lucrative growth over the forecast period with a CACR of 17.26%. The segment's growth is expected to be driven by the increase in the number of clinical trials for advanced therapy medicinal products. In addition, biomarker discovery and disease modeling are also anticipated to propel segment growth by 2032.

End-use Insights

Based on end-use, the gene synthesis market is segmented into academic & government research institutes, biotechnology & pharmaceutical companies, and contract research organizations (CROs). The academic & government research institutions segment dominated the market with a revenue share of 44% in 2023. The segment's dominance is due to expanding research prospects aimed at exploring the use of gene synthesis for studying model organisms. Moreover, enhanced flexibility and automation in gene synthesis facilitated a growing penetration of the technique in research laboratories. Collaborations between industry and academia are expected to boost segment growth over the coming years.

The contract research organization end-use segment is expected to witness the fastest CAGR of 18.25% throughout the forecast period. The growing number of small biotechnology companies and increasing outsourcing trends are anticipated to impact segment growth in the forthcoming years.

Europe Gene Synthesis (Research Use) Market Key Companies

• GenScript
• Azenta, Inc. (GENEWIZ)
• Boster Biological Technology
• Twist Bioscience
• ProteoGenix, Inc
• Biomatik
• ProMab
• Thermo Fisher Scientific, Inc.
• Integrated DNA Technologies, Inc. (Danaher)
• OriGene Technologies, Inc.

Europe Gene Synthesis (Research Use) Market Segmentations:

By Method 

• Solid-phase Synthesis
• Chip-based Synthesis
• PCR-based Enzyme Synthesis

By Service 

• Antibody DNA Synthesis
• Viral DNA Synthesis
• Others

By Application 

• Gene & Cell Therapy Development
• Vaccine Development
• Others

By Research Phase 

• Pre-clinical
• Clinical

By End-use 

• Biotechnology and Pharmaceutical Companies
• Academic and Government Research Institutes
• Contract Research Organizations